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Publications

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Toxicology

Disease modelling

Bioinformatics

Gene editing

Regenerative medicine

Cryopreservation

Genetic reprogramming

Nuclear transfer and Embryology

Others

Toxicology

Human Induced Pluripotent Stem Cell-Derived 3D-Neurospheres Are Suitable for Neurotoxicity Screening

J. Kobolak; A. Teglasi; T. Bellak; Z. Janstova; K. Molnar; M. Zana; I. Bock; L. Laszlo; A. Dinnyes

in Cells. 2020

doi: 10.3390/cells9051122

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

Pamies D, Bal-Price A, Chesné C, Coecke S, Dinnyes A, Eskes C, Grillari R, Gstraunthaler G, Hartung T, Jennings P, Leist M, Martin U, Passier R, Schwamborn JC, Stacey GN, Ellinger-Ziegelbauer H, Daneshian M

in ALTEX. 2018

doi: 10.14573/altex.1710081

In Vitro Acute and Developmental Neurotoxicity Screening: An Overview of Cellular Platforms and High‑Throughput Technical Possibilities

Z. Schmidt, M. Lehmann, S. Gutbier, E. Nembo, S. Noel, L. Smirnova, A. Forsby, J. Hescheler, H. X. Avci, T. Hartung, M. Leist, J. Kobolák, A. Dinnyes.

in Archives of Toxicology, 2016

doi: 10.1007/s00204-016-1805-9,

Drug discovery models and toxicity testing using embryonic and induced pluripotent stem-cell-derived cardiac and neuronal cells

Deshmukh, RS., Kovács, KA., Dinnyes, A.

in Stem Cells International. 2012

doi: 10.1155/2012/379569. 

Disease modelling

Alzheimer’s Disease

 

The role of P2X7 receptor in Alzheimer's disease

L. Francistiová, C. Bianchi, C. Di Lauro, Á. Sebastián-Serrano, L. de Diego-García, J. Kobolák, A. Dinnyes, M. Díaz-Hernández

in Frontiers in Molecular Neuroscience 2020, 13 (94).

doi: 10.3389/fnmol.2020.00094

Live cell imaging of single neurotrophin receptor molecules on human neuron in Alzheimer’s disease

K. Barabás, J. Kobolák, S. Godó, D. Ernszt, M. Kecskés, Cs.Varga, J.Kardos, T.Z. Jánosi, T.Fujiwara, A.Kusumi, A.Téglási, A. Dinnyes, I. M. Ábrahám

in bioRxiv. 2020.

doi: 10.1101/2020.02.17.953174

Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAβPPα Release from PSEN1 Mutant iPSC-Derived Neurons

Lo Giudice M, Mihalik B, Turi Z, Dinnyes A, Kobolák J.

in  J Alzheimers Dis. 2019

doi: 10.3233/JAD-190602.

The Nervous System Relevance of the Calcium Sensing Receptor in Health and Disease

Giudice ML, Mihalik B, Dinnyes A, Kobolák J.

in Molecules.  2019

doi: 10.3390/molecules24142546 Review.

Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels and GSK3B activation

Ochalek, A; B Mihalik; HX. Avci; A Chandrasekaran; A Téglási; I Bock; M L Giudice; Z Táncos; K Molnár; L László; JE Nielsen; B Holst; K Freude; P Hyttel; J Kobolák; A Dinnyes

in Alzheimer’s Research & Therapy 2017

doi: 10.1186/s13195-017-0317-z

Establishment of Induced Pluripotent Stem Cell (iPSC) Line from a 63-Year Old Patient with Late Onset Alzheimer's Disease (Load)

Chandrasekaran, A., Varga, E., Nemes, Cs., Táncos, Zs., Kobolák, J., Dinnyes. A.

in Stem Cell Research

doi: 1016/j.scr.2016.05.014

Establishment of induced pluripotent stem cell (iPSC) line from a 75-year old patient with late onset Alzheimer's disease (LOAD)

Zs., Táncos, E., Varga, E., Kovács, , Dinnyes, J., Kobolák

in Stem Cell Research, 2016

doi: 10.1016/j.scr.2016.05.013

Establishment of Psen1 Mutant Induced Pluripotent Stem Cell (Ipsc) Line from an Alzheimer's Disease (Ad) Female Patient

Cs., Nemes, E., Varga, Zs., Táncos, I., Bock, B., Francz, J., Kobolák, A., Dinnyes

in Stem Cell Research, 2016

doi: 0.1016/j.scr.2016.05.019

Establishment of induced pluripotent stem cell (iPSC) line froma 57-year old patient with late onset Alzheimer's disease (LOAD)

A., Ochalek, Cs., Nemes, E., Varga , Zs., Táncos, J., Kobolák, A.,Dinnyes

in Stem Cell Research, 2016

doi:10.1016/j.scr.2016.05.020,

Generation of Induced Pluripotent Stem Cells (iPSCs) from an Alzheimer’s Disease Patient Carrying a M146i Mutation in Psen1.

T., Li, C., Pires, T.T., Nielsen, G., Waldemar, L.E., Hjermind, J. E. Nielsen, A., Dinnyes, B.,Holst, P.,Hyttel, K., K. Freude

in Stem Cell Research, 2016

doi:10.1016/j.scr.2016.01.001

Generation of Induced Pluripotent Stem Cells (iPSCs) from an Alzheimer’s Disease Patient Carrying a A79v Mutation in Psen1.

T., Li, C., Pires, T.T., Nielsen, G., Waldemar, L.E., Hjermind, J. E. Nielsen, A., Dinnyes, B., Holst, P.,Hyttel, K., K. Freude

in Stem Cell Research, 2016

doi: 10.1016/j.scr.2016.01.002

Autism Spectrum disorder

Establishment of an induced pluripotent stem cell (iPSC) line from a 9-year old male with autism spectrum disorder (ASD)

Varga E, Nemes, Cs, Bock, I, Táncos, Zs, Berzsenyi, S, Lévay, Gy, Román, V, Kobolák, J., Dinnyes, A.

in Stem Cell Research, 2017

doi: 10.4049/jimmunol.1600034

Altered neurite morphology and cholinergic function of induced pluripotent stem cell-derived neurons from a patient with Kleefstra syndrome and autism

J Nagy, J. K., S Berzsenyi, Z Ábrahám, H X Avci, I Bock, Z Bekes1, B Hodoscsek, A Chandrasekaran, A Téglási, P Dezső1, B Koványi, E T Vörös, L Fodor, T Szél, K Németh, A Balázs, A Dinnyes, B Lendvai, G Lévay, V Román

in Translational Psychiatry, 2017

doi: 10.1038/tp.2017.144

Establishment of EHMT1 mutant induced pluripotent stem cell (iPSC) line from a 11-year-old Kleefstra syndrome (KS) patient with autism and normal intellectual performance

Varga, E., Nemes, Cs., Táncos, Zs., Bock, I., Berzsenyi, S., Lévay, Gy., Román, V., Kobolák, J., Dinnyes, A.

in Stem Cell Research, 2016

doi: 10.1016/j.scr.2016.09.031

Targeted Next Generation Sequencing of a Panel of Autism-Related Genes Identifies an Ehmt1 Mutation in a Kleefstra Syndrome Patient with Autism and Normal Intellectual Performance

Bock, I., Németh, K., Pentelényi, K., Balicza, P., Balázs, A., Molnár, M. J, Románd, V, Nagy, J., Lévay, Gy., Kobolák, J., Dinnyes, A.

in Gene, 2016

doi: 10.1016/j.gene.2016.09.027

Lysosomal storage disorders

Generation of human induced pluripotent stem cell line UNIGEi001-A from a 2-years old patient with Mucopolysaccharidosis type IH disease

Lito S, Burda P, Baumgartner M, Sloan-Béna F, Táncos Z, Kobolák J, Dinnyes A, Krause KH, Marteyn A.

in Stem Cell Res, 2019

doi: 10.1016/j.scr.2019.101604

Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells

Kobolák J, Molnár K, Varga E, Bock I, Jezsó B, Téglási A, Zhou S, Lo Giudice M, Hoogeveen-Westerveld M, Pijnappel WP, Phanthong P, Varga N, Kitiyanant N, Freude K, Nakanishi H, László L, Hyttel P, Dinnyes A.

in Exp Cell Res. 2019

doi: 10.1016/j.yexcr.2019.04.021

Generation of human induced pluripotent stem cell (iPSC) line from an unaffected female carrier of Mucopolysaccharidosis Type II (MPS II) disorder

Varga, E., Nemes, Cs., Kovács, E., Bock, I., Varga, N., Fehér, A., Dinnyes, A., Kobolák, J.

in Stem Cell Research, 2016

doi: 10.1016/j.scr.2016.09.035

Generation of Mucopolysaccharidosis type II (MPS II) human induced pluripotent stem cell (iPSC) line from a 1-year-old male with pathogenic IDS mutation

Varga, E., Nemes, Cs., Kovács, E., Bock, I., Varga, N., Fehér, A., Dinnyes, A., Kobolák, J.

in Stem Cell Research, 2016

doi: 10.1016/j.scr.2016.09.033

Generation of Mucopolysaccharidosis type II (MPS II) human induced pluripotent stem cell (iPSC) line from a 3-year-old male with pathogenic IDS mutation

Varga, E., Nemes, Cs., Kovács, E., Bock, I., Varga, N., Fehér, A., Kobolák, J. Dinnyes, A.

in Stem Cell Research, 2016

doi: 10.1016/j.scr.2016.09.032

Generation of Mucopolysaccharidosis Type II (MPS II) human induced pluripotent stem cell (iPSC) line from a 7-year-old male with pathogenic IDS mutation

Varga E, Bock, I., Varga, N., Fehér, A., Kobolák, J., Dinnyes, A.

in Stem Cell Research, 2016

doi: 10.1016/j.scr.2016.09.034

Others

Enhancement of b-Globin Gene Expression in Thalassemic IVS2-654 Induced Pluripotent Stem Cell-Derived Erythroid Cells by Modified U7 snRNA

Phathong, P., Borwornpinyo, S.; Kitiyanant, N., Jearawiriyapaisarn, N., Nunzakarn, L., Saetan, J. Nualkaew, T. Sa-Ngiamsuntorn, K.; Anurathapan, U., Dinnyes, A, Kitiyanant, Y.Hongeng, S.

in Stem Cells Translational Medicine, 2017

doi: 1002/sctm.16-0121

Generation of Cholinergic and Dopaminergic Interneurons from Human Pluripotent Stem Cells as a Relevant Tool for In Vitro

Ochalek, A., Szczesna, K., Petazzi, P., Kobolak, J., Dinnyes, A.

in Modeling of Neurological Disorders Pathology and Therapy Stem Cells International, 2016

doi: 10.1155/2016/5838934

Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research

Chandrasekaran, A., Avci, H.X., Leist, M., Kobolák, J., Dinnyes, A.

in Frontiers in Cellular Neuroscience, 2016

doi: 10.3389/fncel.2016.00215

In Vitro Models of Cancer Stem Cells and Clinical Applications

S. Franco S., Szczesna, K., Iliou. M., Al-Qahtani, M., Mobasheri, A., Kobolák, J., Dinnyes, A

in BMC Cancer, 2016

doi: 10.1186/s12885-016-2774-3

The positional identity of iPSC-derived neural progenitor cells along the anterior-posterior axis is controlled in a dosage-dependent manner by bFGF and EGF

Zhou S, Ochalek A, Szczesna K, Avci HX, Kobolák J, Varga E, Rasmussen M, Holst B, Cirera S, Hyttel P, Freude KK, Dinnyes, A

in Differentiation, 2016

doi: 10.1016/j.diff.2016.06.002

Neurosphere based differentiation of human iPSC improves astrocyte differentiation

S. Zhou, K. Szczesna, A. Ochalek, J. Kobolák, E. Varga, Cs. Nemes, A. Chandrasekaran, M. Rasmussen, S. Cirera, P. Hyttel, A. Dinnyes, K.K Freude, H. X. Avci

in Stem Cells International, 2016

doi: 10.1155/2016/4937689

Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human iPSCs

Chandrasekaran, A, Avci, HX, Ochalek, A, Rösingh, LN, Molnár, K, László, L, Bellák, T, Téglási, A, Pesti, K, Mike, A, Phanthong, Biro, O, Hall, V, Kitiyanant, N, Krause, KH, Kobolák, J Dinnyes A.

in Stem Cell Research, 2017

doi: 10.1016/j.scr.2017.10.010

The crossroads between cancer stem cells and aging

Santos Franco, S., Raveh-Amit, H., Kobolák, J., Alqahtani, MH., Mobasheri, A., Dinnyes, A.

in BMC Cancer, 2015

doi: 10.1186/1471-2407-15-S1-S1

Bioinformatics

Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states

Dirks RAM, van Mierlo G, Kerstens HHD, Bernardo AS, Kobolák J, Bock I, Maruotti J, Pedersen R, Dinnyes, A. A, Huynen MA, Jouneau A, Marks H.

in Epigenetics Chromatin, 2019

doi: 10.1186/s13072-019-0259-8.

Positioning Europe for the EPITRANSCRIPTOMICS challenge

Jantsch MF, Quattrone A, O’Connell M, Helm M, Frye M, Macias-Gonzales M, Ohman M, Ameres S, Willems L, Fuks F, Oulas A, Vanacova S, Nielsen H, Bousquet-Antonelli C, Motorin Y, Roignant JY, Balatsos N, Dinnyes A, Baranov P, Kelly V, Lamm A, Rechavi G, Pelizzola M, Liepins J, Holodnuka Kholodnyuk I, Zammit V, Ayers D, Drablos F, Dahl JA, Bujnicki J, Jeronimo C, Almeida R, Neagu M, Costache M, Bankovic J, Banovic B, Kyselovic J, Valor LM, Selbert S, Pir P, Demircan T, Cowling V, Schäfer M, Rossmanith W, Lafontaine D, David A, Carre C, Lyko F, Schaffrath R, Schwartz S, Verdel A, Klungland A, Purta E, Timotijevic G, Cardona F, Davalos A, Ballana E, O Carroll D, Ule J, Fray R

in RNA Biol, 2018

doi: 10.1080/15476286.2018.1460996

A Mammalian embryo comparison identifies novel pluripotency genes associated with the naïve or primed state

A.S. Bernardo, Jouneau A, Marks H, Kensche P, Kobolak J, Freude K, Hall V, Feher A, Polgar Z, Sartori C, Bock I, Louet C, Faial T, Kerstens HHD, Bouissou C, Parsonage G, Mashayekhi K, Smith JC, Lazzari G, Hyttel P, Stunnenberg HG, Huynen M, Pedersen R, Dinnyes, A.

in Biol Open, 2018

doi: 10.1242/bio.033282

Controlled hydrostatic pressure stress downregulates the expression of ribosomal genes in preimplantation embryos - a possible protection mechanism?

Bock, I., Raveh-Amit, H., Losonczi, E., Carstea, A. C. ., Feher, A., Mashayekhi, K., Matyas,S., Dinnyes, A., and Pribenszky,C.

in Reproduction, Fertility and Development, 2014

doi: 10.1071/RD14346

iTRAQ proteome analysis reflects a progressed differentiation state of epiblast derived versus inner cell mass derived murine embryonic stem cells

Fröhlich, T., Kösters, M.,Graf, A.,Wolf, E.,Kobolak, J.,Brochard, V.,Dinnyes, A.,Jouneau, A.,Arnold, G. J.

in Journal of Proteomics, 2013

doi: dx.doi.org/10.1016/j.jprot.2013.03.015

Gene editing

A single amino acid switch converts the Sleeping Beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming

Kesselring L, Miskey C, Zuliani C, Querques I, Kapitonov V, Laukó A, Fehér A, Palazzo A, Diem T, Lustig J, Sebe A, Wang Y, Dinnyes A, Izsvák Z, Barabas O, Ivics Z..

in Nucleic Acids Res, 2020

doi: 10.1093/nar/gkz1119.

Lack of Rybp in Mouse Embryonic Stem Cells Impairs Cardiac Differentiation

Ujhelly, O., Szabo, V., Kovacs, G., Vajda, F., Mallok, S., Prorok, J., Acsai, K., Hegedus, Z., Krebs, S., Dinnyes, A., Pirity, MK.

in Stem Cells Development, 2015.

doi:10.1089/scd.2014.0569

Regenerative medicine

Grafted human induced pluripotent stem cells improve the outcome of spinal cord injury: modulation of the lesion microenvironment

T.Bellák , Z. Fekécs , D. Török , Zs.Táncos , Cs.Nemes , Zs.Tézsla , L.Gál, S.Polgári , J. Kobolák , A.Dinnyés , A. Nógrádi , K. Pajer

in Nature, 2020

doi: 10.1038/s41598-020-79846-2

The Potency of Induced Pluripotent Stem Cells in Cartilage Regeneration and Osteoarthritis Treatment

Murphy C, Mobasheri A, Táncos Z, Kobolák J, Dinnyes A.

in Adv Exp Med Biol, 2018

doi: 10.1007/5584_2017_141.

Real architecture For 3D Tissue (RAFTTM) culture system improves viability and maintains insulin and glucagon production of mouse pancreatic islet cells

Szebeni, J.G, Tancos, Zs., Feher, l.Z., Alfoldi, R., Kobolak, J., Dinnyes, A, Puskas L.G.

in Cytotechnology, 2017

doi: 10.1007/s10616-017-0067-6

Mesenchymal stem cells: Identification, phenotypic characterization, biological properties and potential for regenerative medicine through biomaterial micro-engineering of their niche

Kobolak J, Dinnyes, A., Memic, A., Khademhosseini, A., Mobasheri, A.

in Methods,  2016

doi: 10.1016/j.ymeth.2015.09.016

Veterinary applications of induced pluripotent stem cells: regenerative medicine and models for disease?

Cebrian-Serrano, A., Stout, T., Dinnyes, A.

in Veterinary Journal, 2013

doi: 10.1016/j.tvjl.2013.03.028. Review.

Grafted murine induced pluripotent stem cells prevent death of injured rat motoneurons otherwise destined to die

Pajer, K., Nemes, C., Berzsenyi, S., Kovács, KA., Pirity, MK., Pajenda, G., Nógrádi, A., Dinnyes, A.

in Experimental Neurology, 2015

doi: 10.1016/j.expneurol.2015.03.031

Cryopreservation

Vitrified sheep isolated secondary follicles are able to grow and form antrum after a shortperiod of in vitro culture

Lunardi, FO., Chaves RN, de Lima, LF., Araújo, VR., Brito, IR., Souza, CE., Donato, MA., Peixoto, CA., Dinnyes, A., Campello, CC., de Figueiredo, JR., Rodrigues, AP.

in Cell and Tissue Research, 2015

doi: 10.1007/s00441-015-2181-0

In vitro fertilization of ovine oocytes vitrified by solid surface vitrification at germinal vesicle stage

Moawad, A.R., Fisher, P., Zhu, J., Choi,I., Polgar, Z., Dinnyes,A.,Campbell, K.H.S.

in Cryobiology, 2012

doi: 10.1016/j.cryobiol.2012.04.008

Effect of vitrification on mitochondrial distribution and membrane potential in mouse two pronuclear (2-PN) embryos

Zhao, XM., Fu, XW., Hou, YP., Yan, CL., Suo, L., Wang, YP., Zhu, HB., Dinnyes, A, Zhu, SE.

in Molecular Reproduction Development, 2009

doi: 10.1002/mrd.21064

Determination of oocyte membrane permeability coefficients and their application to cryopreservation in a rabbit model

Liu, J., Mullen, S., Meng, Q., Critser, J., Dinnyes, A.

in Cryobiology, 2009

doi: 10.1016/j.cryobiol.2009.06.002.

Cryopreservation of manipulated embryos: tackling the double jeopardy

Dinnyes, A.,Nedambale, T.L.

in Reproduction, Fertility and Development, 2009

doi: 1071/RD08220

The effect of breed on the survivability and motility rate of cryopreserved cock semen

Makhafola, B, Lehloenya , K.C., Mphaphathi, M.L., Dinnyes, A.  Nedambale, T.L.

in South African Journal of Animal Science, 2009

doi: 10.4314/sajas.v40i5.65348

Novel gamete storage

Dinnyes, A., Liu, J., Nedambale, T.L.

in Reproduction, Fertility and Development, 2007

doi: dx.doi.org/10.1071/RD07035

Developmental competence of in vitro-fertilized porcine oocytes after in vitro maturation and solid surface vitrification: effect ofcryopreservation on oocyte antioxidative system and cell cycle stage

Somfai, T., Ozawa, M., Noguchi, J., Kaneko, H., Kuriani Karja, NW., Farhudin, M., Dinnyes, A., Nagai, T., Kikuchi, K.

in Cryobiology, 2007

doi:10.1016/j.cryobiol.2007.06.008

Effects of vitrification procedures on subsequent development and ultrastructure of in vitro-matured swampbuffalo (Bubalus bubalis) oocytes

Boonkusol, D., Faisaikarm, T., Dinnyes, A., Kitiyanant, Y.

in Reproduction Fertility Development, 2007

doi:1071/RDv19n1Ab109

Gene Expression Profiles and In Vitro Development Following Vitrification of Pronuclear and 8-Cell Stage Mouse

Boonkusol, D., Baj Gal, A., Bodo Sz., Gorhony, B.,  Kitiyanant, y.,  Dinnyes, A.

in Molecular Reproduction and Development, 2006

doi: 10.1002/mrd.20450

Invitro fertilization of ovine oocytes vitrified by solid surface vitrification at germinal vesicle stage

Moawad, AR., Fisher, P., Zhu, J., Choi, I., Polgar, Z., Dinnyes, A., Campbell, KH.

in Cryobiology,  2012

doi:10.1016/j.cryobiol.2012.04.008. Epub 2012 May 3.

Effect of human beta-globin bacterial artificial chromosome transgenesis on embryo cryopreservation in mouse models

Boonkusol,D., Dinnyes, A, Faisaikarm, T., Sangsuwan, P., Pratipnatalang, N., Sa-Ardrit, M., Saikhun, K., Svasti, S., Vadolas, J., Winichagoon, P., Fucharoen, S., Kitiyanant, Y.

in Reproduction and Fertility Develeopment, 2010

doi: 10.1071/RD09128.

Generation of induced pluripotent stem cells from mouse embryonic fibroblasts by sleeping beauty transposon gene delivery system

Muenthaisong, S., Ujhelly, O., Varga, E., Ivics, Z., Pirity, M., Dinnyes, A.

in Transgenic Research, 2010

doi: 10.1016/j.diff.2013.06.002

Development to the blastocyst stage of parthenogenetically activated in vitro matured porcine oocytes after Solid Surface Vitrification (SSV)

Somfai, T., Dinnyes, A., Sage, D., MMarosan, M., Carnwath, JW., Ozawa, M., Kikuchi, K., Niemann, H.

in Theriogenology, 2006

doi: 1016/j.theriogenology.2005.11.023

Comparative studies with six extenders for sperm cryopreservation in the cynomolgus monkey (Macaca fascicularis) andrhesus monkey (Macaca mulatta)

Li, Y., Cai, K., Li, J., Dinnyes, A., Ji, W.

in American Journal of Primatololgy, 2006

doi: 1002/ajp.20205

Prolonging bovine sperm-oocyte incubation in modified medium 199 improves embryo development rate and the viability of vitrified blastocysts

Nedambale, T.L., Du, F., Xu, J., Chaubal,SA., Dinnyes, A., Groen, W., Faber, D., Dobrinsky, J.R., YANG, X., TIAN, X.C.

in Theriogenology, 2006

doi: 10.1016/j.theriogenology.2006.04.044.

Developmental Potential of Vitrified Holstein Cattle Embryos Fertilized in Vitro with Sex-sorted Sperm

Xu, J., Zhiqin, G., Lei, S., Nedambale, T.L., Jiain, Z., Schenk, J., Moreno, J.F., Dinnyes, A., Weizhi, J, Tian, X.C., Xiangzhong, Y., Du, F.

in Journal of Dairy Science, 2006

doi: 10.3168/jds.S0022-0302(06)72326-8

Vitrification of biopsied mouse embryos

Baranyai, B.,Bodo, sz., Dinnyes, A., Gocza, E.

in Acta Veterinaria Hungarica, 2005

doi: doi.org/10.1556/AVet.53.2005.1.10

Genetic reprogramming

Establishment of a rabbit induced pluripotent stem cell (RbiPSC) line using lentiviral delivery of human pluripotency factors

Táncos Zs, Nemes, Cs, Varga, E, Bock, I., Rungarunlert, S., Tharasanit, T, Techakumphu, M, Kobolak, J, Dinnyes, A.

in Stem Cell Research, 2017

doi: 10.1016/j.scr.2017.03.010

Cloning and characterization of rabbit POU5F1, SOX2, KLF4, C-MYC and NANOG pluripotency-associated genes

Táncos, Z., Bock, I., Nemes, C., Kobolák, J., Dinnyes, A.

in Gene, 2015

doi: 10.1016/j.gene.2015.04.034.

Generation of transgene-free mouse induced pluripotent stem cells using an excisable lentiviral system

Varga, E., Nemes, C., Davis, R.D., Ujhelly, O., Klincumhom, N., Polgar, Z., Muenthaisong, S., Pirity, M.K. and Dinnyes, A.

in Experimental Cell Research, 2014

doi: 10.1016/j.yexcr.2014.02.006

Strategies for rapidly mapping proviral integration sites and assessing cardiogenic potential of nascent human induced pluripotent stem cell clones

Dambrot, C., Buermans, HP., Varga,E., Kosmidis, G., Langenberg, K., Casini, S., Elliott, DA., Dinnyes, A., Atsma, DE., Mummery, CL., Braam, SR,, Davis, RP.

in Experimental Cell Research, 2014

doi: 10.1016/j.yexcr.2014.05.001

Generation of mouse induced pluripotent stem cells by protein transduction

Nemes, C., Varga, E., Polgar, Z., Klincumhom, N., Pirity, MK., Dinnyes, A.

in Tissue Engineering Part C Methods, 2014

doi: 10.1089/ten.TEC.2013.0026

Is aging a barrier to reprogramming? Lessons from induced pluripotent stem cells

Phanthong, P., Raveh-Amit, H., Li, T., Kitiyanant, Y., Dinnyes, A.

in Biogerontology, 2013

doi: 10.1007/s10522-013-9455-2

Generation of induced pluripotent stem cells from human foetal fibroblasts using the Sleeping Beauty transposon gene delivery system

Davis, RP., Nemes, C., Varga, E., Freund, C., Kosmidis, G., Gkatzis, K., de Jong, D., Szuhai, K., Dinnyes, A., Mummery, CL..

in Differentiation, 2013

doi: 10.1016/j.diff.2013.06.002

Generation of neuronal progenitor cells and neurons from mouse sleeping beauty transposon-generated induced pluripotent stem cells

Klincumhom, N., Pirity, MK., Berzsenyi, S., Ujhelly, O., Muenthaisong, S., Rungarunlert, S., Tharasanit T, Techakumphu,M., Dinnyes, A.

in Cellular Reprogramming, 2012

doi: 10.1089/cell.2012.0010

Generation of mouse induced pluripotent stem cells from different genetic backgrounds using Sleeping beauty transposon mediated gene transfer

Muenthaisong, S., Ujhelly, O., Polgar, Z., Varga, E., Ivics, Z., Pirity, MK., Dinnyes, A.

in Experimental Cell Research, 2012

doi: 10.1016/j.yexcr.2012.07.014

Temporal repression of endogenous pluripotency genes during reprogramming of porcine induced pluripotent stem cells

Hall, VJ., Kristensen, M., Rasmussen, MA., Ujhelly, O., Dinnyes, A., Hyttel, P.

in Cellular Reprogramming, 2012

doi: 10.1089/cell.2011.0089

Generation of rabbit pluripotent stem cell lines

Tancos, Zs., Nemes, Cs., Polgar, Zs., Gocza, E., Daniel, N., Stout, T.A.E., Maraghechi, P.Pirity, M.K.Osteil, P.Tapponnier, Y.Markossian, S.Godet, M.Afanassieff, M.Bosze, Zs.Duranthon, V., Savatier, P., Dinnyes, A.

in Theriogenology, 2012

doi: 10.1016/j.theriogenology.2012.06.017

Promoter analysis of the rabbit POU5F1 gene and its expression in preimplantation stage embryos

Kobolak, J., Kiss, K., Polgar, Z., Mamo, S., Rogel-Gaillard, C., Tancos, Z., Bock, I., Baji, AG., Tar, K., Pirity, MK., Dinnyes, A.

in BMC Molecular Biology, 2009

doi: 10.1186/1471-2199-10-88

Nuclear transfer and Embryology

Beneficial Effect of Melatonin on Blastocyst In Vitro Production from Heat-Stressed Bovine Oocytes

Cebrian-Serrano, A., Salvador, I.,Raga, E., Dinnyes, A., Silvestre, M.A.

in Reproduction in Domestic Animals, 2013

doi: 1111/rda.12154

Phenotypic Comparison Of Four Thalassemia Model Mice Reconstructed From Cryo-banked Embryos

Boonkusol, D., Dinnyes, A. Sa-Ardrit, M. Svasti, S. Faisaikarm, T. Vadolas, J. Fucharoen, S. Kitiyanant, Y.

in Acta Biologica Hungarica, 2013

doi: 10.1556/ABiol.64.2013.4.5

Controlled Stress Improves Performance - Cell Preconditioning in Assisted Reproduction

Pribenszky, C., Lin, L.,Du, Y.,Losonczi, E.,Dinnyes, A., Vajta, G.

in Reproduction in Domestic Animals, 2012

doi: 10.1111/j.1439-0531.2012.02076.x

Effect of Oocyte Heat Stress and Melatonin on In Vitro Production of Bovine Embryos

Cebrian-Serrano, A., Salvador, I.,Raga, E.,Dinnyes, A.,Silvestre, M.A.

in Reproduction in Domestic Animals. 2012

Comparative analysis of nuclear transfer embryo-derived mouse embryonic stem cells. Part II: gene regulation

Kobolak, J., Horsch, M., Geissler, S., Mamo, S., Beckers, J., Dinnyes, A.

in Cellular Reprogramming, 2012

doi: 10.1089/cell.2011.0057

Comparative analysis of nuclear transfer embryo-derived mouse embryonic stem cells. Part I: cellular characterization

Kobolak, J., Mamo, S., Rungsiwiwut, R., Ujhelly, O., Csonka, E., Hadlaczky, G., Dinnyes, A.

in Cellular Reprogramming, 2012

doi: 10.1089/cell.2011.0056

Comparative characterization of four mouse parthenogenetic embryonic stem (pES) cell lines

Rungarunlert, S., Rungsiwiwut, R., Suphankong, S., Panasophonkul, S., Kamthorn, P., Pramuan, V. Pirity, MK., Dinnyes, A., Tharasanit, T.,  Techakumphu, M.

in Thai Journal of Veterinary Medicine, 2011

Review of somatic cell nuclear transfer in pig

Muenthaisong, S., Dinnyes,A., Nedambale, TL.

in Academic Journals African Journal of Biotechnology, 2011

doi: 10.5897/AJB11.2082

Stress tolerance and transcriptional response in mouse embryos treated with high hydrostatic pressure to enhance cryotolerance

Bock, I., Losonczi, E., Mamo, S., Polgar, Z., Harnos, A., Dinnyes, A., Pribenszky, C.

in CryoLetters, 2010  

doi: 1038/srep21215

Tbx3: another important piece fitted into the pluripotent stem cell puzzle

Pirity, MK., Dinnyes, A.

in Stem Cell Ressearch and Therapy, 2010  

doi: 10.1186/scrt12

Generation of mouse embryonic stem cell lines from zona-free nuclear transfer embryos

Kobolak, J., Bodo, S., Rungsiwiwut, R., Meng, Q., Adorjan, M., Virutamasen, P., Techakumphu, M., Dinnyes, A.

in Cellular Reprograming, 2010 

doi: 10.1089/cell.2009.0040

Germline competence of mouse ES and iPS cell lines: Chimera technologies and genetic background

Carstea, A.C, Pirity, MK., Dinnyes, A.

in World Journal Stem Cells, 2009 

doi:10.4252/wjsc.v1.i1.22

Nucleolar Re-Activation Is Delayed in Mouse Embryos Cloned From Two Different Cell Lines Molecular

Svarcova,O.,Dinnyes, A., Polgar, Z., Bodo, S., Adorjan, M., Meng, Q., Maddox-Hyttel, P.

in Reproduction Fertility and Development, 2009 

doi: 10.1002/mrd.20936

Live birth of somatic cell-cloned rabbits following trichostatin A treatment and cotransfer of parthenogenetic embryos

Meng, Q., Polgar, Z., Liu, J., Dinnyes, A.

in Cloning Stem Cells, 2009  

doi: 10.1089/clo.2008.0072

Cotransfer of parthenogenetic embryos improves the pregnancy and implantation of nuclear transfer embryos in mouse

Meng, Q., Wang, M., Stanca, CA., Bodo, S., Dinnyes A.

in Cloning Stem Cells, 2008   

doi: 10.1089/clo.2008.0003

Epigenetic regulation of foetal development in nuclear transfer animal models

Dinnyes, A., Tian, XC., Yang, X.

in Reproduction In Domestic Animals, 2008    

doi: 10.1111/j.1439-0531.2008.01178.x

Expression profiles of the pluripotency marker gene POU5F1 and validation of reference genes in rabbit oocytes and preimplantation stage embryos

Mamo, S., Gal, A.B., Polgar, Z., Dinnyes, A.

in BMC Mol Biol, 2008     

doi: 10.1186/1471-2199-9-67

Transfert nucléaire et cellules souches embryonnaires chez le lapin (Nuclear transfer and embryonic stem cells technology in rabbits).

Polgar, Z., Dinnyes, A.

in Biofutur, 2008

In vitro development of polyspermic porcine oocytes: Relationship between early fragmentation and excessive number of penetrating spermatozoa

Somfai, T., Ozawa, M., Noguchi, .J, Kaneko, H., Karja, NW., Fahrudin, M., Nakai, M., Maedomari, N., Dinnyes, A., Nagai, T., Kikuchi, K.

in Animal Reproduction Science, 2008

doi: 10.1016/j.anireprosci.2007.06.025

Piezo-actuated zona-drilling improves the fertilisation of OPS vitrified mouse oocytes

Meng, Q., Li, X., Wu, T., Dinnyes, A.

in Acta Vet. Acta Veterinaria Hungarica, 2007

doi: 10.1556/AVet.55.2007.3.11

Quantitative evaluation and selection of reference genes in mouse oocytes and embryos cultured in vivo and in vitro

Mamo, S., Gal, AB., Bodo, S., Dinnyes, A.

in BMC Developmental Biology, 2007

doi: 10.1186/1471-213X-7-14

Diploid porcine parthenotes produced by inhibition of first polar body extrusion during in vitro maturation of follicular oocytes

Somfai, T., Ozawa,M.,Noguchi, J., Kaneko,H., Ohnuma,K., Karja, NWK., Fahrudin, M., Maedomari, N., Dinnyes,A., Nagai,T., Kikuchi, K.

in Reproduction Fertility  and Development, 2006

doi: 10.1530/rep.1.01216

Gene expression profiles of vitrified in vivo derived 8-cell stage mouse embryos detected by high density oligonucleotide microarrays

Mamo, S., Bodo, S., Kobolak, J., Polgar, Z., Tolgyesi, G., Dinnyes, A.

in Mol Reprod Dev, 2006

doi: 10.1002/mrd.20588

Comparison of real-time polymerase chain reaction and end-point polymerase chain reaction for the analysis of gene expression in preimplantation embryos

Gál, AB., Carnwath, JW., Dinnyes, A., Herrmann, D., Niemann, H., Wrenzycki, C.

in Reproduction Fertililty Development, 2006

doi: 10.1071/rd05012

Animal cloning by nuclear transfer: state-of-the-art and future perspectives

Dinnyes, A., Szmolenszky, A.

in Acta biochemica Polonica, 2005

doi: 10.18388/abp.2005_3418

Others

Light sheet fluorescence microscopy versus confocal microscopy: in quest of a suitable tool to assess drug and nanomedicine penetration into multicellular tumor spheroids

Lazzari G, Vinciguerra D, Balasso A, Nicolas V, Goudin N, Garfa-Traore M, Fehér Dinnyes, A. A, Nicolas J, Couvreur P, Mura S.

in Eur J Pharm Biopharm, 2019

doi: 10.1016/j.ejpb.2019.06.019

Three-dimensional analysis of nuclear heterochromatin distribution during early development in the rabbit

Bonnet-Garnier A, Kiêu K, Aguirre-Lavin T, Tar K, Flores P, Liu Z, Peynot N, Chebrout M, Dinnyes A, Duranthon V, Beaujean N.

in Chromosoma, 2018

doi: 10.1007/s00412-018-0671-z

A fragment-based NMR study provides atomic-resolution information on the conformational dynamics in the proneural bHLH transcription factor Ascl1

Barontim L., Hošek, T., Gil-Caballero, S., Raveh-Amit, H., Calçada, E.O., Ayala, I., Dinnyes, A., Felli, I.C., Pierattelli, R.

in Biophysical Journal, 2017

doi: 10.1016/j.bpj.2017.02.025.

Immunogenic Dendritic Cell Generation from Pluripotent Stem Cells by Ectopic Expression of Runx3

Takacs E, Boto P, Emilia Simo, Csuth TI, Toth BM, Raveh-Amit H, Pap A, Kovács EG, Kobolak J, Benkö S, Dinnyes, A., Szatmari I.

in Journal of Immunology, 2017

doi:  10.4049/jimmunol.1600034

Systematic in Vitro and in Vivo Characterization of Leukemia-Inhibiting Factor- And Fibroblast Growth Factor-Derived Porcine Induced Pluripotent Stem Cells

Secher, J.O., Ceylan, A., Mazzoni, G., Mashayekhi, K., Li, T., Muenthaisong, S., Nielsen, T.T., Li, D., Li, S., Petkov, S., Cirera, S.,  Luo, Y.,Thombs, L., Kadarmideen, H., N.,  Dinnyes, A., Bolund, L., Roelen , B. A. J., Schmidt, M., Callesen, H.,  Hyttel, P.,  Freude, K.K.

in Molecular Reproduction & Development, 2017

doi: 10.1002/mrd.22771

Antimicrobial resistance of Lactobacillus spp. from fermented foods and human gut

Q., Ma., Y., Fu, H., Sun, Y., Huang, L., Li, Q., Yu,  A., Dinnyes, Q. Sun.

in LWT – Food Science and Technology, 2017

doi: 10.1016/j.lwt.2017.07.059

Human three-dimensional engineered neural tissue reveals cellular and molecular events following cytomegalovirus infection

Cosset, É., Martine, Y., Preynat-Seauve, O., Lobrinus, JA., Tapparel, C., Cordey, S., Peterson, H., Petty, TJ., Colaianna, M., Tieng, V., Tirefort, D., Dinnyes, A., Dubois-Dauphin, M., Kaiser, L., Krause, KH.

in Biomaterials, 2015

doi: 10.1016/j.biomaterials.2015.02.094

Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord

Lovrics. A, Gao, Y., Juhász B., Bock, I, Byrne, HM., Dinnyes, A., Kovács, KA.

in PLoS One, 2014

doi: 10.1371/journal.pone.0111430

Selective TGF-β1/ALK inhibitor improves neuronal differentiation of mouse embryonic stem cells

Klincumhom, N., Tharasanit, T., Thongkittidilok, C., Tiptanavattana, N., Rungarunlert, S., Dinnyes, A., Techakumphu, M.

in Neuroscience Letters, 2014

doi: 10.1016/j.neulet.2014.06.001

 

Cytoprotection by the NO-Donor SNAP Against Ischemia/Reoxygenation Injury in Mouse Embryonic Stem Cell-Derived Cardiomyocytes

Gorbe, A., Varga, ZV., Paloczi, J., Rungarunlert, S., Klincumhom, N., Pirity, M., Madonna, R., Eschenhagen, T., Dinnyes, A., Csont, T., and Ferdinandy, P.

in Molecular Biotechnology, 2014

doi: 10.1007/s12033-013-9704-2

 

Screening of bioactive peptides using an embryonic stem cell-based neurodifferentiation assay

Xu R., Feyeux, M., Julien, S., Nemes, C., Albrechtsen, M., Dinnyes A., Kraus, KH.

in AAPS Journal, 2014

doi: 10.1208/s12248-014-9578-7

 

Autophagy is required for zebrafish caudal fin regeneration

Klionsky, D. J., Varga, M., Sass, M., Papp, D., Takacs-Vellai, K., Vellai, T., Kobolak, J., Dinnyes, A.

in Cell Death and Differentiation, 2014

doi:  10.1038/cdd.2013.175

 

Cytoprotection by the NO-Donor SNAP Against Ischemia/Reoxygenation Injury in Mouse Embryonic Stem Cell-Derived Cardiomyocytes

Gorbe, A., Z.V. Varga, J. Paloczi, S. Rungarunlert, N. Klincumhom, M. Pirity, R. Madonna, T. Eschenhagen, Dinnyes, A., Csont, T., Ferdinandy, P.

in Molecular Biotechnology, 2014

doi: 10.1007/s12033-013-9704-2

 

Tissue resident stem cells: till death do us part

Raveh-Amit, H., Berzsenyi, S., Vas, V., Ye, D., Dinnyes, A.

in Biogerontology, 2013

doi: 10.1007/s10522-013-9469-9 Review.

Age influence on hypersensitivity pneumonitis induced in mice by exposure to Pantoea agglomerans

Lemieszek, MK., Chilosi, M., Golec, M., Skórska, C., Dinnyes, A., Mashayekhi, K.,Vierlinger, K., Huaux, F., Wielscher, M., Hofner, M., Yakoub, Y., Pastena, C., Daniele, I.,Cholewa, G., Sitkowska, J., Lisowska, W., Zwoliński, J., Milanowski, J., Mackiewicz, B.,Góra-Florek, A., Ziesche, R., Dutkiewicz, J.

in Inhalation Toxicology, 2013

doi: 10.3109/08958378.2013.827284

Slow turning lateral vessel bioreactor improves embryoid body formation and cardiogenic differentiation of mouse embryonic stem cells

Rungarunlert, S., Klincumhom, N., Tharasanit, T., Techakumphu, M., Pirity, MK., Dinnyes, A.

in Cellular Reprogrammig, 2013

doi: 10.1089/cell.2012.0082

Modulating neurogenesis in embryoid body using a selective TGF beta1/ALK inhibitor affects on gene expression of embryonic stem cell-derived motor neurons.

Klincumhom, N., Tharasanit, T.,Thongkittidilok, C.,Tiptanavattana, N., Dinnyes, A., Techakumphu, M.

in Thai Journal of Veterinary Medicine, 2013

TYK2 kinase activity is required for functional type I interferon responses in vivo

Prchal-Murphy, M., Semper, C., Lassnig,C., Wallner, B., Gausterer, C., Teppner-Klymiuk, I., Kobolak, J., Müller, S., Kolbe, T., Karaghiosoff, M., Dinnyes, A., Rülicke, T., Leitner, NR., Strobl, B., Müller, M.

in PLoS One, 2012

doi: 10.1371/journal.pone.0039141

 

Preliminary evaluation of the different glycerol concentrations on boar semen parameters stored at 5 and 18 °C

Masenya, M.B., Mphaphati, M.L, P.P.,M., D.O.,U., Dinnyes, A., Nedambale T.

in UNISWA Journal of Agriculture, 2011

 

Seven ages of the PhD

Gosling, R., Tickle, C., Running, SW., Tandong, Y., Dinnyes, A., Osowole, AA., Cule, E.

in Nature2011

doi: 10.1038/472283a 

Enhanced cardiac differentiation of mouse embryonic stem cells by use of the slow-turning, lateral vessel (STLV) bioreactor

Rungarunlert, S., Klincumhom, N., Bock, I., Nemes, C., Techakumphu, M., Pirity, MK., Dinnyes, A.

in Biotechnology Letters, 2011

doi: 10.1007/s10529-011-0614-8

Identification of pluripotency marker genes in rabbit pre-implantation-stage embryos

Tancos, Z., Kobolak, J., Baji, G:A., and Dinnyes,A.

in Magyar Állatorvosok Lapja, 2010

Gene targeting and Calcium handling efficiencies in mouse embryonic stem cell lines

Mamo, S., Kobolak, J., Borbíró,I., Bíró,T., Bock,I., Dinnyes,A.

in World Journal of Stem Cells, 2010

doi: 10.4252/wjsc.v2.i6.127

Embryoid body formation from embryonic and induced pluripotent stem cells: Benefits of bioreactors

Rungarunlert, S., Techakumphu, M., Pirity, MK., Dinnyes, A.

in World Journal Stem Cells2009

doi: 10.4252/wjsc.v1.i1.11