Closed H2020 and other international projects

Directing the immune response through designed nanomaterials

H2020-MSCA-ITN-2020
Number of participants: 12 + 5
Role: Associated partner
Project number: H2020-MSCA-ITN-2020-956544

Objective: DIRNANO provides a highly integrated and interdisciplinary training of next-generation Early Stage Researchers (ESRs) at the interface of nanopharmaceutical bioengineering and its translation on preclinical and human immunology.

DIRNANO will develop biocompatible nanopharmaceuticals with either “super”-stealth or immune-specific behavior for cancer immunotherapy and vaccination by mapping nanoparticle-immune interactions through two core approaches: 1) inception of novel surface engineering approaches, based on new organic polymers, zwitterionic lipids and conjugation chemistry strategies, 2) engineering of host or microbial-derived modulators of innate immunity (e.g. complement system).

DIRNANO team comprises internationally renowned scientists and industrialists at the forefront of nanoengineering, pharmaceutical sciences, molecular biosciences, commerce and business, thereby generating a unique pan-European macro-environment for interdisciplinary training of ESRs at the highest international level. Through participation of industrial partners, we will furnish ESRs with in-demand industrial and business skills, including process manufacturing, reproducibility and regulatory challenges, intellectual property and commercialization strategies.

DIRNANO will lead to rational engineering of broader libraries of NPs with tunable immune-modulating functions. The combinatorial analysis of new nanomaterial core-coat scaffolds will improve temporal and spatial understanding of biomaterial-innate immune interactions at the molecular level, thereby filling the void in overcoming adverse reactions to nanopharmaceuticals injection. DIRNANO will drive future development of small molecules and biologics-based nanopharmaceuticals through a “low-risk-high gain” perspective and within the context of personalized therapies and precision medicine. As such, DIRNANO, will extensively contribute to European science, education and socioeconomics value, skill retention and brain-gain.

Integration of Nano- and Biotechnology for Beta-cell and Islet Transplantation

H2020-NMBP-2016-2017 (Call for Nanotechnologies, Advanced Materials, Biotechnology and Production)
Number of participants: 8
Role: Coordinator
Project number: H2020-NMBP-15-2017-760986

Objective: The iNanoBIT project is aimed to apply nanotechnologies for imaging porcine pancreatic islet cellular transplants and induced pluripotent stem cell-derived beta-cells and subsequent regenerative processes in vivo in a porcine model. The project will develop1) novel highly sensitive nanotechnology-based imaging approaches allowing for monitoring of survival, engraftment, proliferation, function and whole body distribution of the cellular transplants in a preclinical porcine model with excellent translational potential to humans; 2) develop and validate the application of state-of-the-art imaging technologies facilitating the provision of new regenerative therapies to preclinical large animal models and patients; 3) directly contribute to the opening of a new market sector for i) imaging equipment (SPECT, PET/MR, optoacoustic imaging in preclinical large animal models and patients), ii) nano-imaging molecule supplies (nanomolecules allowing multimodality imaging of specific cell types with high sensitivity), iii) validated transplantable in vitro differentiated human beta-cells and porcinexenotransplant islets thus will reinforce the European healthcare supply chain for regenerative medicinal products. The iNanoBIT project will provide the currently missing toolbox for preclinical/clinical testing for a safe translation of regenerative medicinal cellular and tissue products, currently under preclinical and clinical trials, which is vital for the competitiveness of the European healthcare sector in this fast-growing area. The consortium of 5 SME and 3 Academic partners is coordinated and driven by the industrial partners from the field of nanotechnology, imaging and stem cell technologies, providing a perfect match and unique combination addressing the scope and expected impact of the call and providing TRL 3/4 starting points for the key technological elements, and expect to arrive to TRL6 levels of validated technologies ready for marketing by the end of the project.

Periconceptional Programming of Health Training Network

H2020-MSCA-ITN-2018 — Marie Skłodowska-Curie Innovative Training Networks
Type of action: MSCA-ITN-ETN (European Training Networks)
Number of participants: 20
Role: Coordinator
Project number: Project No. 812660
Project website: http://dohartnet.eu/

Altered conditions during the periconceptional (PC) period of gamete maturation and early embryonic development have long lasting effects on the health of the progeny, including the childhood, adolescent and adult-life onset of cardiovascular, metabolic and neurological diseases (‘Developmental Origins of Health and Disease (DOHaD) concept).
Increasing evidence from epidemiological and animal model studies shows that children worldwide exhibit conditions and disease risks associated with the exposures of their parents, including chemical stressors before and during pregnancy, reproductive failure, adverse pregnancy outcome, diabetes, obesity and nutritional compromise.
Babies born following human ART (“testtube”) interventions render this population (over 6 million world-wide) one of the largest well-defined clinical cohorts to be studied for a better understanding of the future risk of disease for current and succeeding generations in Europe.

The DohART-NET project focus on the integration of pre-clinical (animal and stem cell-models) and clinical studies and apply data linkage, bioinformatics and network science for the identification and validation of mechanisms of diseases common in early development. The project will exploit our new understanding to promote efficient disease prevention and potential personalised therapeutic interventions in both the general and ART populations to overcome adverse disease pathways.
DohART-NET is optimized for training ESRs due to the facts that: 1.) the topic is progressive, and much needed to improve public health over several generations, and it is integrating basic pre-clinical, translational clinical and in silico modeling approaches. 2.) the partnership has a highly multi- and interdisciplinary scientific and training expertise and excellence 3.) there is an existing synergy by collaborations and links that the partners wish to strengthen both in science and lasting training programs in a highly inter-sectorial setting.
Specific ESR individual projects will make a major contribution to the goals of the project and along with secondments are fully integrated into the overall research programme.

Transport derived Ultrafines and the Brain Effects

EU H2020 Research and innovation actions (RIA)
Participant’s number: 14
Role: Partner
Project number: H2020-MG-2018-2019-2020
Project website: https://www.tube-project.eu/

Objective: The aim of the research is to study the effects of smallest traffic related ultrafine- or nanoparticles beyond the lung on brain health. Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include impairment of many respiratory (e.g. asthma, COPD) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming more evident. Neurological diseases, namely Alzheimer´s disease (AD) has shown to be associated with living near traffic. However, reason for this has remained unresolved until today. This consortium aims on revealing the mechanisms and exposures both behind cardiorespiratory diseases and beyond the current knowledge in neurological diseases. This consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant toxic effect of these air pollutants. In this study, we will investigate adverse effects of air pollutants using cell cultures, animal exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the art to neurotoxic and brain health effects. With this approach, we are aiming in to a comprehensive understanding of the adverse effects of nanoparticles from traffic. In current situation only particles above 23nm are measured in regulations, traditional toxicological methods are used in risk assessment and emission inventories and regulations are largely based on old technology engines. Our project will change this.

From air pollution to brain pollution – novel biomarkers to unravel the link of air pollution and Alzheimer’s disease

JPND call for proposals: “Multinational research projects on Personalised Medicine for Neurodegerative Diseases”

Number of participants: 8
Role: Partner
Project number: 250619
Project website:  https://adair-jpnd.eu/

Objective: Despite decades of Alzheimer’s disease (AD) research, the real molecular pathophysiology of the disease is still poorly understood, and treatments remain inadequate. Remarkably little attention is paid to the involvement of environmental factors, which are known from epidemiological studies to strongly impact AD development. Air pollution, a massive public health issue known to pose a major threat to humans, is an increasing global concern. A growing body of evidence from epidemiological and controlled animal studies shows that exposure to air pollutants also impairs the brain. Furthermore, living in highly polluted areas is associated exacerbated cognitive dysfunction and AD. However, many questions remain unanswered as mechanistic information on air pollutant effects is scarce. Importantly, biomarkers for air pollution and AD risk prediction do not currently exist, thus hindering the identification and stratification of individuals at risk for harmful air pollution effects.
Drawing upon a unique combination of expertise and state-of-the-art methods and tools in neurobiology, epidemiology, clinical science, environmental science and data science, the ADAIR consortium is uniquely placed to, for the first time, provide crucial mechanistic insight about the effects of air pollutants on the brain in humans and discover biomarkers for air pollution and AD risk prediction. ADAIR applies a precision medicine approach to stratify individuals to subgroups for risk estimation and future AD prevention, ultimately aiming to target air pollution induced effects in those individuals that can most benefit from them. The project investigates the novel, ambitious hypothesis that the pollutant exposure environment of an individual alters cellular mechanisms and functions, resulting in the expression of measurable biomarkers. By identifying biomarkers, the individuals with increased AD risk can be stratified prior to the disease onset and preventive measures can be targeted to the specific at-risk populations in order to be most effective.

ADAIR address a major societal challenge with wide health-related, environmental, economic, scientific, social, and political impact. Lowering the burden of AD attributable to air pollution and contribution to the mitigation of climate change, are closely linked. The ultimate goal is to develop strategies for early identification of people at risk of AD, and to discover novel targets for preventive strategies to reduce the health care and socio-economic burden of AD.

An integrated interdisciplinary approach to animal-free nanomaterial and chemical safety assessment.

Marie Curie – Innovative Training Network (ITN)
Participant’s number: 13
Role: Participant
Project number: H2020-MSCA-ITN-2016 – 721975
Project website: estiv.org/in3/

Objective: The in3 project is a Marie Curie Innovative Training Network that aims to drive the synergistic development and utilisation of in vitro and in silico tools for human chemical and nanomaterial (NM) safety assessment. The project will focus on differentiation of human induced Pluripotent Stem Cells (hiPSC) to toxicologically relevant target tissues including; brain, lung, liver and kidney. The tissues, from the same genetic backgrounds, will be exposed to several compounds and the data generated will be used to develop safety assessment approaches by integrating cheminformatics, mechanistic toxicology and biokinetics into computational models. The project will hire 15 PhD students to carry out these activities in a coordinated and highly collaborative fashion. The scientists trained within in3 will acquire a unique multidisciplinary skill set giving them a competitive employment advantage in safety assessment sciences either in industry, governmental bodies or academia.

Core scientific activities:

•  Differentiation of well-characterised human iPSC into brain, lung, liver, kidney and vascular cells
•  Delineation of tissue specific and donor specific effects of compound exposures (uptake, metabolism, extrusion, and mechanistic toxicity)
•  Development and optimisation of quantitative adverse outcome pathways (qAOPs) for each target organ which will be unified in an organism-level model
•  Optimisation of QSAR and read-across tools for safety assessment
•  Ultimately to create a unified expandable integrated testing strategy for chemical and NM safety assessment

Interdisciplinary training network on the purinergic P2X7 receptor to control neuroinflammation and hyperexcitability in brain diseases

H2020-MSCA-ITN-2017
Marie Skłodowska-Curie Actions Innovative Training Networks (ITN)
Number of participants: 9
Role: Participant
Project number: H2020-MSCA-ITN-2017- 766124
Project website: https://cordis.europa.eu/project/id/766124

Objective: Brain disorders affect ~179 million people and their families in Europe alone, with an annual cost to the taxpayer estimated at €800 billion- a greater economic burden than cardiovascular disease and cancer combined. Despite diverse etiology, overlap in clinical symptoms and comorbidities between brain disorders suggests shared patho-mechanisms. In particular, hyperexcitible states driven by glial activation and neuroinflammation appear near ubiquitous. Targeting these mechanisms offers the potential to ameliorate symptoms and reverse disease progression across a broad span of brain disorders. Functioning as a gatekeeper to neuroinflammation and mechanistic link between neuronal hyperexcitability and glial activation, the ATP-gated, ionotropic purinergic P2X7 receptor (P2X7R) offers the most promising target for pharmacological intervention in the neuroinflammation-hyperexcitability pathway, to date. With breakthroughs in understanding P2X7R function, highly promising effects demonstrated for antagonists in models of brain disease and vast investment in P2X7Rrelated drug development programmes, now is the perfect time to pool resources. PurinesDX brings together global leaders in translational research in purinergic signalling, Europe’s leading clinical specialists in a broad range of brain diseases, and industrial partners specializing in drug and biomarker development.

Calcium-Sensing Receptor (CaSR): Therapeutics for Non-Communicable Diseases

EU H2020 Marie Sklodowska-Curie Innovative Training Networks (ITN)
Participant’s number: 13
Role: Participant
Project number: H2020-MSCA-ITN-2015 – 675228
Project website:casr.meduniwien.ac.at/

Objective: The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer, which account for >25% of the global disease burden. The CaSR is a unique GPCR whose principal physiological ligand is the Ca2+ ion; it is expressed almost ubiquitously; interacts with multiple Gα subtypes regulating highly divergent downstream signalling pathways, depending on the cellular context. The CaSR Biomedicine is a fully translational project that utilises the concept of a single molecule, the CaSR, influencing a range of physiological and disease processes, to develop a unique, strong multidisciplinary and intersectoral scientific training programme preparing 14 young scientists to become specialists in GPCR biology and signalling.The objectives of CaSR Biomedicine are:1. Educate and train Early Stage Researchers to become highly innovative scientists to enhance their career perspective. 2. Elucidate ligand- and tissuedependent differences in CaSR physiology by examining its functions at cellular level and thus to contribute to the understanding of GPCR signalling in general; 3. Assess how CaSR function is altered in AD, CVD, DM, sarcopenia, and cancer, and to find innovative CaSR-based therapeutic approaches for these major, age-related disorders.4. Establish long-lasting interdisciplinary and intersectoral cooperation among researchers and between researchers and industry, to strengthen the European Research Area.Therefore the CaSR Biomedicine will investigate the complexity of CaSR signalling and function to identify CaSR-based therapeutic approaches to diseases linked to changes in CaSR expression or function (AD, CVD, DM, sarcopenia, and cancer).

Next Generation Science Challenges Using Digital and Social Media to Make Science Education and Careers Attractive for Young People

EU H2020 Industrial Leadership and Societal Challenges Department, Spreading Excellence, Widening Participation, Science with and for Society (SEAC)
Participant’s number: 9
Role: Partner
Project number: H2020-SEAC-2014-2015 – 665868
Project website: www.scichallenge.eu

Objective: Science education is tremendous in shaping the present and future of modern societies. Thus, the EU needs all its talents to increase creativity and competitiveness. Especially young boys and girls have to be engaged to pursue careers in Science, Technology, Engineering and Mathematics (STEM). However, statistics still show that enrolment rates in STEM-based degree programs are low and will lead to a workforce problem in industries, especially in many of the new member countries. The SciChallenge project focuses on developing novel concepts to actively integrate young boys and girls in science education using a contest-based approach to self-produced digital education materials from young people for young people. Driven by inspirational topic sheets, guides and toolkits created through this project and distributed by partner schools, teachers, and other youth-oriented institutions, contestants (individuals or groups) between the ages of 10 to 20 will generate creative digital materials (videos, slides, or infographics). The initiative will broadcast and distribute content over various social media channels and aggregated on a modern SciChallenge Web Platform (www.scichallenge.eu) to generate wide reaching awareness and promotion. Winning submissions will receive prizes funded by science-oriented industry and stakeholders. Intelligent cross-sectoral positioning of various awareness modules on the SciChallenge Open Information Hub will increase awareness on science careers and open opportunities for youngsters on internships or taster days in STEM through the strong involvement of related organisations and industries. Additionally aggregated information on science events (slams, nights, festivals etc.) is shared. With this multi-level approach, SciChallenge will boost the attractiveness of science education and careers among young girls and boys leading to more public engagement in science, economic prosperity and global competitiveness on a pan-European level.

Design and development of advanced NAnomedicines to overcome Biological Barriers and to treat severe diseases

EU H2020 Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN)
Participant’s number: 6
Role: Associated Partner
Project number: H2020-MSCA-ITN-2014- 642028
Project website: www.nabbaproject.eu

Objective: Many therapeutic targets are shielded behind biological barriers, limiting the possibility to reach them with conventional drugs or diagnostic probes. Biological barriers are even more problematic for most biological pharmaceutics, such as recombinant proteins, antibodies and gene therapeutics. The most promising solution to this challenge is the use of nano-vehicles for specific targeting and delivery. The aim of NABBA is to form European early stage researchers (ESR) with cutting-edge scientific knowledge in the field of nanoparticles (NP) for biomedical application, able to cross biological barriers. For this aim the project will train ESRs, focusing on key aspects of nanobiotechnology: (i) design and chemical synthesis of different types of NPs, (ii) related techniques of detection and characterization, (iii) strategies of loading, targeting and delivery of drugs or diagnostic probes; (iv) proof of principle of pharmacological activity including pharmacokinetics and biodistribution. As a peculiar feature of NABBA, strong emphasis will be devoted to molecular mechanisms ruling biological barriers under physiological and pathological conditions, in order to develop novel nano-technological expedients for their crossing. Strong emphasis will be devoted to advanced chemistry issues, enabling new synthetic strategies either for NP assembly or functionalization. Different biological barriers will be addressed. ESRs will strongly benefit from a network of internationally recognized scientists in the field of chemistry, nanobiotechnology and nanomedicine, and the participation of companies with relevant interests and expertises in the field. The planned cooperation programs between Academia and Industries will allow the circulation of ESRs and this will give them the opportunity for to get acquainted with the most advanced research in the field, the most sophisticated technologies and the most advanced Industrial manufacturing platforms and innovative strategies.

V4RM – Bridging the gap between science, education and enterprise in regenerative medicine

Number of Participants: 5
Role: Partner
Project number: 22020272

Project website: https://v4rm.net/en/

Objective: The mission of the V4RM network is to provide an interface between science, education and business communities involved in the field of Regenerative Medicine in Visegrad countries and Ukraine.

The network is intended to become a basis for the establishment of wide consortia of organizations for generating future collaborative grant applications, promotion of student exchanges and growth of competitiveness of organizations within the world.

We believe gaining the best practices from the neighbouring countries would bridge the gap in the communication and bring significant long-lasting impact in the development of the regenerative medicine in the region. We expect to increase the success rate of our collaborative research projects, young scientist exchanges, as well as improve the overall business/research/education cooperation.

The project is co-financed by the Governments of Czechia, Hungary, Poland and Slovakia through Visegrand Grants from International Visegrad Fund. The mission of the fund is to advance ideas for sustainable regional cooperation in Central Europe.

Setting an interdisciplinary/sectorial/international research network to explore dry storage as an alternative strategy for cells/germplasm biobanking

H2020-MSCA-RISE-2016
(Marie Skłodowska-Curie Research and Innovation Staff Exchange)
Number of participants: 8
Role: Participant
Project number: H2020-MSCA-RISE-2016-734434
Project website: https://sites.google.com/unite.it/drynet/

Objective: The number of biobanks for diagnostic/clinical/biodiversity preservation purposes is increasing exponentially, representing an economic burden for the EU. Cryopreservation (Liquid Nitrogen LN) is the only cells/gametes long-term repository method. LN storage is expensive though, requires dedicated facilities, is hazardous, carries pathogens and has high carbon footprint. DRYNET objective is to set an inter-sectorial/multidisciplinary/international network between EU academic (5), SME (3), the EU pan-Biobank, and international partners (Japan/Thailand), with the aim of sharing knowhow & expertise to lay down the theoretical and early empirical basis for the dry storage of cells/germplasm. DRYNET merges the partner’s expertise, theoretical/ biophysical/ mathematical modelling, cellular/ molecular/ insect biology, embryology, mechanical engineering into a coherent approach towards dry storage of cells/germplasm. International/inter-sectorial secondments, with meeting/workshop/summer school will be primary tools to implement our strategy for biobanking. Outreaching activities will guarantee public awareness of the project. DRYNET’s relies on water subtraction to induce a reversible block of metabolism, a survival strategy available in nature (anhydrobiosis). The work plan foresees the exploitation of natural xero-protectants (Late Embryogenesis Abundant proteins), loaded/expressed in gametes/cells, before drying. The best drying approaches, supported by theoretical/biophysical/math modelling, will be implemented by SMEs/academy partners. DRYNET will bring a simplification of currents practices, with cost and carbon footprint reduction, for the maintenance/shipping of biobanks. DRYNET will generate young scientists with transferable skills, ensuring career prospect in academia/industry. DRYNET strengthens the international/sectorial network between different disciplines, ensures long-term sustainability of the project, and boosts European competitiveness in biobanking.

An Integrated EUropean ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century

EU H2020 Research and innovation actions (RIA)
Participant’s number: 25
Role: Partner
Project number: H2020-PHC-2015-single-stage_RTD- 681002
Project website: https://www.eu-toxrisk.eu/

Objective: The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemicals with little background information. The project will focus on repeated dose systemic toxicity (liver, kidney, lung and nervous system) as well as developmental/reproduction toxicity. Different human tiered test systems are integrated to balance speed, cost and biological complexity. EU-ToxRisk extensively integrates the adverse outcome pathway (AOP)-based toxicity testing concept. Therefore, advanced technologies, including high throughput transcriptomics, RNA interference, and high throughput microscopy, will provide quantitative and mechanistic underpinning of AOPs and key events (KE). The project combines in silico tools and in vitro assays by computational modelling approaches to provide quantitative data on the activation of KE of AOP. This information, together with detailed toxicokinetics data, and in vitro-in vivo extrapolation algorithms forms the basis for improved hazard and risk assessment. The EU-ToxRisk work plan is structured along a broad spectrum of case studies, driven by the cosmetics, (agro)-chemical, pharma industry together with regulators. The approach involves iterative training, testing, optimization and validation phases to establish fit-for-purpose integrated approaches to testing and assessment with key EU-ToxRisk methodologies. The test systems will be combined to a flexible service package for exploitation and continued impact across industry sectors and regulatory application. The proof-of-concept for the new mechanism-based testing strategy will make EU-ToxRisk the flagship in Europe for animal-free chemical safety assessment.

Stem Cell Center of Excellence in Neurology

Program: Innovation Fund Denmark

Number of Participants: 12 partners and 3 external collaborators
Role: External collaborator
Project number: 4108-00008B

Project website:  https://brainstem.dk/

Objective: Objective/abstract: The key objective of BrainStem is to improve therapy and diagnostics of AD, FTD, and PD by development and application of patient-specific iPSC-derived in vitro and in vivo models. Scientifically, the objective is to use these models to investigate molecular and cellular disease mechanisms in patient-specific neurons and glial cells by applying front-line methodologies in transcriptomics and proteomics. This includes the development of improved protocols for in vitro neural differentiation, derivation of gene-edited control and disease cell lines, as well as aggravation of molecular pathology by genetic modification. Industrially, the objective is to use the established in vitro and in vivo models and the generated knowledge for identifying new targets and validating existing drug targets. Societally, the objective is to use the iPSC in vitro cell models for development of cell-based tools for earlier and stratified AD diagnosis, and thus enhanced treatment outcome, life quality, and reduced health care budgets. Ethically, we will analyse and propose strategies for how to deal with issues with broad societal significance, focusing on concerns over privacy and autonomy when obtaining consent for biobanking. Thus, BrainStem will directly use patient-specific stem cell tools for improved and sustainable treatment and diagnostics providing exciting industrial opportunities.

Closed FP6 and FP7 projects

Closed national projects

A kedvezményezett neve: BioTalentum Tudásfejlesztő Kft.

Felhívás: Szellemi alkotások hazai és nemzetközi szellemitulajdon-védelmét szolgáló tevékenységek támogatása az alkotások hasznosulásának előmozdítása érdekben (2020-1.1.3-IPARJOG)

A projekt azonosítószáma: 2020-1.1.3-IPARJOG-2022-00289

A projekt címe: Új, stabil riportert kifejező, humán indukált pluripotens őssejt vonal

A BioTalentum Tudásfejlesztő Kft. részére, a Nemzeti Kutatási, Fejlesztési és Innovációs Alapból megítélt támogatási összeg: 600 000 Ft

A BioTalentum Tudásfejlesztő Kft. által elszámolható összköltség: 600 000 Ft

A projekt futamideje: 2022.05.11-2022.06.30.

A projekt szakmai összefoglalója: A BioTalentum Kft. 2005-ben alapított vállalkozói kutatóhely. A cég fő tevékenységi köre az őssejttenyésztést, génmanipulált sejtes és állatmodellek előállítását magába foglaló biotechnológiai kutatás-fejlesztés, illetve ezek eredményeinek piaci hasznosítása – orvos biológiai kutatások, valamint gyógyszer tesztelés céljára használható új modellek kutatása és létrehozása, valamint tudományos / technológiai szolgáltatások nyújtása akadémiai és gyógyszergyári kutatócsoportok számára. A BioTalentum Kft. partnerként szerepel számos Európai Uniós FP6-os, FP7-es, valamint az új keretprogram H2020-as projektekben, szakmai koordinátorként a tudományos szakmai munka mellett megalkotja a koncepciót, összeállítja a konzorciumot, magas színvonalú szakmai anyagot készít a konzorciumi tagok segítségével és megfelelő formában benyújtja azt. Jelen projektben a cég szellemi alkotásainak hazai és nemzetközi szellemitulajdon-védelme és azok hasznosulásának előmozdítása érdekében a BioTalentum Kft. iparjogvédelmi pályázatát valósítja meg szakmai koordinátorként a 2020-1.1.3-IPARJOG felhívás keretében.

A projekt célja „Új, stabil riportert kifejező, humán indukált pluripotens őssejt vonal” tárgykörű szolgálati találmányhoz kapcsolódóan szabadalomi beadvány előkészítése és benyújtása volt.

A kedvezményezett neve: BioTalentum Tudásfejlesztő Kft.

Felhívás: Az Európai Unió Horizont Európa programjában, valamint egyéb közös EU-s programokban való magyar részvétel ösztönzése (2021-1.2.3-EU_KP)

A projekt azonosítószáma: 2021-1.2.3-EU_KP-2021-00001

A projekt címe: Utólagos támogatás kérése a FetoBrain pályázatra való felkészüléshez

A BioTalentum Tudásfejlesztő Kft. részére, a Nemzeti Kutatási, Fejlesztési és Innovációs Alapból megítélt támogatási összeg: 2 000 000 Ft

A BioTalentum Tudásfejlesztő Kft. által elszámolható összköltség: 2 000 000 Ft

A projekt futamideje: 2021.01.10-2021.05.25.

A projekt szakmai összefoglalója: Az EU-KP pályázat a FetoBrain pályázatra való felkészülés utólagos finanszírozását biztosítja. A FetoBrain célja egy olyan, radikálisan új technológia kidolgozása, mely alkalmas az idegsejtek növekedésének és érésének aktív manipulálására magnetoelektromos nanotranszduktorokkal egy 3D őssejtből származó „miniagyban”. A projekt révén paradigmaváltás valósul meg, amikor egyetlen központi idegrendszeri (CNS) modell helyett egy ún. multi-organ-on-a-chip (mOoC) alkalmazható, melyen a szervezet komplexitásában vizsgálható pl.: a káros környezeti tényezők hatása a fejlődő magzati agyra, komplexen vizsgálva a korai magzati agy fejlődését a placenta – vér-agy gát (BBB) – központi idegrendszer tengelyen keresztül. A FetoBrain célja egy új modell kidolgozása az idegrendszeri fejlődési rendellenességek (ASD, skizofrénia) kialakulásában szerepet játszó káros hatások megértésére. A teszt rendszerben az adott betegségben szenvedő egyénből humán indukált pluripotens őssejteket (hiPSC) fogunk előállítani, melyekből neuron és glia sejteket fogunk differenciáltatni 3D „miniagy” formában, magnetoelektromos nanotranszduktorokkal stimulálva. A magnetoelektromos nanotranszduktorok alkalmazása a sejtek differenciáltatását felgyorsíthatja, valamint irányíthatóvá válhat az idegsejtek közötti kapcsolatok elrendeződése, mely jelentős előrelépést jelentene a jelenleg hozzáférhető rendszerekhez képest.

A projekt címe: Reagens és szolgáltatás csomag kialakítása gyógyszerek abszorpciójának – disztribúciójának – metabolizmusának – eliminációjának (ADME) vizsgálatához

A projekt azonosító száma: GINOP-2.2.1-15-2016-00009

A (fő)kedvezményezett neve: SOLVO Biotechnológiai ZRT.

Konzorciumi partnerek:

Szegedi Tudományegyetem
Szegedi Biológiai Kutatóközpont
BioTalentum Tudásfejlesztő Kft.
Biospirál-2006. Fejlesztő és Tanácsadó Kft.

A szerződött támogatás összege: 560 723 629 Ft

A támogatás mértéke: 78.94%

A BioTalentum Tudásfejlesztő Kft. támogatás intenzitása: 75%

A projekt megvalósítás időszaka: 2016.05.02. – 2021.05.01.

A projekt tartalmának bemutatása: A pályázat a gyógyszerek transzportjának és metabolizmusának vizsgálatára olyan reagens és szolgáltatás portfóliót fejleszt, amely azonfelül, hogy hiánypótló a piacon, i) segíti a gyógyszerkutató – fejlesztő cégek és a gyógyszerhatóságok munkáját valamint ii) a gyógyszertranszport jelentőségének megértését. A konzorciumvezető a multidiszciplináris feladatot akadémiai, egyetemi intézetek, kis- és mikrovállalkozások hozzájárulásával igyekszik megvalósítani.