Ongoing H2020 projects

Integration of Nano- and Biotechnology for Beta-cell and Islet Transplantation

Periconceptional Programming of Health Training Network

An Integrated EUropean ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century

An integrated interdisciplinary approach to animal-free nanomaterial and chemical safety assessment.

Interdisciplinary training network on the purinergic P2X7 receptor to control neuroinflammation and hyperexcitability in brain diseases

Setting an interdisciplinary/sectorial/international research network to explore dry storage as an alternative strategy for cells/germplasm biobanking

Transport derived Ultrafines and the Brain Effects

From air pollution to brain pollution – novel biomarkers to unravel the link of air pollution and Alzheimer’s disease

ElectroMechanoActive Polymer-based Scaffolds for Heart-on-Chip

EuroGCT

European consortium for communicating gene- and cell-based therapy information

The projects have received funding from the European Union’s Horizon 2020

iNanoBIT

Integration of Nano- and Biotechnology for Beta-cell and Islet Transplantation

H2020-NMBP-2016-2017 (Call for Nanotechnologies, Advanced Materials, Biotechnology and Production)
Number of participants: 8
Role: Coordinator
Project number: H2020-NMBP-15-2017-760986

Objective: The iNanoBIT project is aimed to apply nanotechnologies for imaging porcine pancreatic islet cellular transplants and induced pluripotent stem cell-derived beta-cells and subsequent regenerative processes in vivo in a porcine model. The project will develop1) novel highly sensitive nanotechnology-based imaging approaches allowing for monitoring of survival, engraftment, proliferation, function and whole body distribution of the cellular transplants in a preclinical porcine model with excellent translational potential to humans; 2) develop and validate the application of state-of-the-art imaging technologies facilitating the provision of new regenerative therapies to preclinical large animal models and patients; 3) directly contribute to the opening of a new market sector for i) imaging equipment (SPECT, PET/MR, optoacoustic imaging in preclinical large animal models and patients), ii) nano-imaging molecule supplies (nanomolecules allowing multimodality imaging of specific cell types with high sensitivity), iii) validated transplantable in vitro differentiated human beta-cells and porcinexenotransplant islets thus will reinforce the European healthcare supply chain for regenerative medicinal products. The iNanoBIT project will provide the currently missing toolbox for preclinical/clinical testing for a safe translation of regenerative medicinal cellular and tissue products, currently under preclinical and clinical trials, which is vital for the competitiveness of the European healthcare sector in this fast-growing area. The consortium of 5 SME and 3 Academic partners is coordinated and driven by the industrial partners from the field of nanotechnology, imaging and stem cell technologies, providing a perfect match and unique combination addressing the scope and expected impact of the call and providing TRL 3/4 starting points for the key technological elements, and expect to arrive to TRL6 levels of validated technologies ready for marketing by the end of the project.

DohART-NET

Periconceptional Programming of Health Training Network

H2020-MSCA-ITN-2018 — Marie Skłodowska-Curie Innovative Training Networks
Type of action: MSCA-ITN-ETN (European Training Networks)
Number of participants: 20
Role: Coordinator
Project number: Project No. 812660
Project website: http://dohartnet.eu/

Altered conditions during the periconceptional (PC) period of gamete maturation and early embryonic development have long lasting effects on the health of the progeny, including the childhood, adolescent and adult-life onset of cardiovascular, metabolic and neurological diseases (‘Developmental Origins of Health and Disease (DOHaD) concept).
Increasing evidence from epidemiological and animal model studies shows that children worldwide exhibit conditions and disease risks associated with the exposures of their parents, including chemical stressors before and during pregnancy, reproductive failure, adverse pregnancy outcome, diabetes, obesity and nutritional compromise.
Babies born following human ART (“testtube”) interventions render this population (over 6 million world-wide) one of the largest well-defined clinical cohorts to be studied for a better understanding of the future risk of disease for current and succeeding generations in Europe.

The DohART-NET project focus on the integration of pre-clinical (animal and stem cell-models) and clinical studies and apply data linkage, bioinformatics and network science for the identification and validation of mechanisms of diseases common in early development. The project will exploit our new understanding to promote efficient disease prevention and potential personalised therapeutic interventions in both the general and ART populations to overcome adverse disease pathways.
DohART-NET is optimized for training ESRs due to the facts that: 1.) the topic is progressive, and much needed to improve public health over several generations, and it is integrating basic pre-clinical, translational clinical and in silico modeling approaches. 2.) the partnership has a highly multi- and interdisciplinary scientific and training expertise and excellence 3.) there is an existing synergy by collaborations and links that the partners wish to strengthen both in science and lasting training programs in a highly inter-sectorial setting.
Specific ESR individual projects will make a major contribution to the goals of the project and along with secondments are fully integrated into the overall research programme.

EU-ToxRisk

An Integrated EUropean ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century

EU H2020 Research and innovation actions (RIA)
Participant’s number: 25
Role: Partner
Project number: H2020-PHC-2015-single-stage_RTD- 681002
Project website: https://www.eu-toxrisk.eu/

Objective: The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemicals with little background information. The project will focus on repeated dose systemic toxicity (liver, kidney, lung and nervous system) as well as developmental/reproduction toxicity. Different human tiered test systems are integrated to balance speed, cost and biological complexity. EU-ToxRisk extensively integrates the adverse outcome pathway (AOP)-based toxicity testing concept. Therefore, advanced technologies, including high throughput transcriptomics, RNA interference, and high throughput microscopy, will provide quantitative and mechanistic underpinning of AOPs and key events (KE). The project combines in silico tools and in vitro assays by computational modelling approaches to provide quantitative data on the activation of KE of AOP. This information, together with detailed toxicokinetics data, and in vitro-in vivo extrapolation algorithms forms the basis for improved hazard and risk assessment. The EU-ToxRisk work plan is structured along a broad spectrum of case studies, driven by the cosmetics, (agro)-chemical, pharma industry together with regulators. The approach involves iterative training, testing, optimization and validation phases to establish fit-for-purpose integrated approaches to testing and assessment with key EU-ToxRisk methodologies. The test systems will be combined to a flexible service package for exploitation and continued impact across industry sectors and regulatory application. The proof-of-concept for the new mechanism-based testing strategy will make EU-ToxRisk the flagship in Europe for animal-free chemical safety assessment.

In3

An integrated interdisciplinary approach to animal-free nanomaterial and chemical safety assessment.

Marie Curie – Innovative Training Network (ITN)
Participant’s number: 13
Role: Partner
Project number: H2020-MSCA-ITN-2016 – 721975
Project website: estiv.org/in3/

Objective: The in3 project is a Marie Curie Innovative Training Network that aims to drive the synergistic development and utilisation of in vitro and in silico tools for human chemical and nanomaterial (NM) safety assessment. The project will focus on differentiation of human induced Pluripotent Stem Cells (hiPSC) to toxicologically relevant target tissues including; brain, lung, liver and kidney. The tissues, from the same genetic backgrounds, will be exposed to several compounds and the data generated will be used to develop safety assessment approaches by integrating cheminformatics, mechanistic toxicology and biokinetics into computational models. The project will hire 15 PhD students to carry out these activities in a coordinated and highly collaborative fashion. The scientists trained within in3 will acquire a unique multidisciplinary skill set giving them a competitive employment advantage in safety assessment sciences either in industry, governmental bodies or academia.

Core scientific activities:

  •  Differentiation of well-characterised human iPSC into brain, lung, liver, kidney and vascular cells
  •  Delineation of tissue specific and donor specific effects of compound exposures (uptake, metabolism, extrusion, and mechanistic toxicity)
  •  Development and optimisation of quantitative adverse outcome pathways (qAOPs) for each target organ which will be unified in an organism-level model
  •  Optimisation of QSAR and read-across tools for safety assessment
  •  Ultimately to create a unified expandable integrated testing strategy for chemical and NM safety assessment

PurinesDX

Interdisciplinary training network on the purinergic P2X7 receptor to control neuroinflammation and hyperexcitability in brain diseases

H2020-MSCA-ITN-2017
Marie Skłodowska-Curie Actions Innovative Training Networks (ITN)
Number of participants: 9
Role: Partner
Project number: H2020-MSCA-ITN-2017- 766124
Project website: http://purinesdx.eu/

Objective: Brain disorders affect ~179 million people and their families in Europe alone, with an annual cost to the taxpayer estimated at €800 billion- a greater economic burden than cardiovascular disease and cancer combined. Despite diverse etiology, overlap in clinical symptoms and comorbidities between brain disorders suggests shared patho-mechanisms. In particular, hyperexcitible states driven by glial activation and neuroinflammation appear near ubiquitous. Targeting these mechanisms offers the potential to ameliorate symptoms and reverse disease progression across a broad span of brain disorders. Functioning as a gatekeeper to neuroinflammation and mechanistic link between neuronal hyperexcitability and glial activation, the ATP-gated, ionotropic purinergic P2X7 receptor (P2X7R) offers the most promising target for pharmacological intervention in the neuroinflammation-hyperexcitability pathway, to date. With breakthroughs in understanding P2X7R function, highly promising effects demonstrated for antagonists in models of brain disease and vast investment in P2X7Rrelated drug development programmes, now is the perfect time to pool resources. PurinesDX brings together global leaders in translational research in purinergic signalling, Europe’s leading clinical specialists in a broad range of brain diseases, and industrial partners specializing in drug and biomarker development.

Drynet

Setting an interdisciplinary/sectorial/international research network to explore dry storage as an alternative strategy for cells/germplasm biobanking

H2020-MSCA-RISE-2016
(Marie Skłodowska-Curie Research and Innovation Staff Exchange)
Number of participants: 8
Role: Partner
Project number: H2020-MSCA-RISE-2016-734434
Project website: https://sites.google.com/unite.it/drynet/

Objective: The number of biobanks for diagnostic/clinical/biodiversity preservation purposes is increasing exponentially, representing an economic burden for the EU. Cryopreservation (Liquid Nitrogen LN) is the only cells/gametes long-term repository method. LN storage is expensive though, requires dedicated facilities, is hazardous, carries pathogens and has high carbon footprint. DRYNET objective is to set an inter-sectorial/multidisciplinary/international network between EU academic (5), SME (3), the EU pan-Biobank, and international partners (Japan/Thailand), with the aim of sharing knowhow & expertise to lay down the theoretical and early empirical basis for the dry storage of cells/germplasm. DRYNET merges the partner’s expertise, theoretical/ biophysical/ mathematical modelling, cellular/ molecular/ insect biology, embryology, mechanical engineering into a coherent approach towards dry storage of cells/germplasm. International/inter-sectorial secondments, with meeting/workshop/summer school will be primary tools to implement our strategy for biobanking. Outreaching activities will guarantee public awareness of the project. DRYNET’s relies on water subtraction to induce a reversible block of metabolism, a survival strategy available in nature (anhydrobiosis). The work plan foresees the exploitation of natural xero-protectants (Late Embryogenesis Abundant proteins), loaded/expressed in gametes/cells, before drying. The best drying approaches, supported by theoretical/biophysical/math modelling, will be implemented by SMEs/academy partners. DRYNET will bring a simplification of currents practices, with cost and carbon footprint reduction, for the maintenance/shipping of biobanks. DRYNET will generate young scientists with transferable skills, ensuring career prospect in academia/industry. DRYNET strengthens the international/sectorial network between different disciplines, ensures long-term sustainability of the project, and boosts European competitiveness in biobanking.

TUBE

Transport derived Ultrafines and the Brain Effects

EU H2020 Research and innovation actions (RIA)
Participant’s number: 14
Role: Partner
Project number: H2020-MG-2018-2019-2020
Project website: https://www.tube-project.eu/

Objective: The aim of the research is to study the effects of smallest traffic related ultrafine- or nanoparticles beyond the lung on brain health. Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include impairment of many respiratory (e.g. asthma, COPD) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming more evident. Neurological diseases, namely Alzheimer´s disease (AD) has shown to be associated with living near traffic. However, reason for this has remained unresolved until today. This consortium aims on revealing the mechanisms and exposures both behind cardiorespiratory diseases and beyond the current knowledge in neurological diseases. This consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant toxic effect of these air pollutants. In this study, we will investigate adverse effects of air pollutants using cell cultures, animal exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the art to neurotoxic and brain health effects. With this approach, we are aiming in to a comprehensive understanding of the adverse effects of nanoparticles from traffic. In current situation only particles above 23nm are measured in regulations, traditional toxicological methods are used in risk assessment and emission inventories and regulations are largely based on old technology engines. Our project will change this.

ADAIR

From air pollution to brain pollution – novel biomarkers to unravel the link of air pollution and Alzheimer’s disease

JPND call for proposals: “Multinational research projects on Personalised Medicine for Neurodegerative Diseases”

Number of participants: 8
Role: Partner
Project number: 250619
Project website:  https://adair-jpnd.eu/

Objective: Despite decades of Alzheimer’s disease (AD) research, the real molecular pathophysiology of the disease is still poorly understood, and treatments remain inadequate. Remarkably little attention is paid to the involvement of environmental factors, which are known from epidemiological studies to strongly impact AD development. Air pollution, a massive public health issue known to pose a major threat to humans, is an increasing global concern. A growing body of evidence from epidemiological and controlled animal studies shows that exposure to air pollutants also impairs the brain. Furthermore, living in highly polluted areas is associated exacerbated cognitive dysfunction and AD. However, many questions remain unanswered as mechanistic information on air pollutant effects is scarce. Importantly, biomarkers for air pollution and AD risk prediction do not currently exist, thus hindering the identification and stratification of individuals at risk for harmful air pollution effects.
Drawing upon a unique combination of expertise and state-of-the-art methods and tools in neurobiology, epidemiology, clinical science, environmental science and data science, the ADAIR consortium is uniquely placed to, for the first time, provide crucial mechanistic insight about the effects of air pollutants on the brain in humans and discover biomarkers for air pollution and AD risk prediction. ADAIR applies a precision medicine approach to stratify individuals to subgroups for risk estimation and future AD prevention, ultimately aiming to target air pollution induced effects in those individuals that can most benefit from them. The project investigates the novel, ambitious hypothesis that the pollutant exposure environment of an individual alters cellular mechanisms and functions, resulting in the expression of measurable biomarkers. By identifying biomarkers, the individuals with increased AD risk can be stratified prior to the disease onset and preventive measures can be targeted to the specific at-risk populations in order to be most effective.

ADAIR address a major societal challenge with wide health-related, environmental, economic, scientific, social, and political impact. Lowering the burden of AD attributable to air pollution and contribution to the mitigation of climate change, are closely linked. The ultimate goal is to develop strategies for early identification of people at risk of AD, and to discover novel targets for preventive strategies to reduce the health care and socio-economic burden of AD.

EMAPS-Cardio

ElectroMechanoActive Polymer-based Scaffolds for Heart-on-Chip

H2020-NMBP-TR-IND-2018-2020 (Call for TRANSFORMING EUROPEAN INDUSTRY)

Number of Participants: 10
Role: Partner
Project number: H2020-NMBP-TR-IND-2018-2020-953138-2

Objective: Cardiovascular diseases (CVDs) account for 45% of deaths in Europe and are estimated to cost the EU economy €210 billion a year. However, only four drugs targeting cardiovascular diseases have been approved for use in the last decade. Thus, models that could effectively simulate diseased tissues, would enable the accurate assessment of the efficacy of the pharmaceuticals, and would accelerate drug development are urgently needed. The main bottleneck towards such models is the foetal-like state of the human induced pluripotent stem cell (hiPSC) derived cardiomyocytes (CMs). That is hiPSC-CMs do not reach adult-like maturity. The objective of this project is to produce a platform for growth and maturation of cardiac microtissues for adult-like organotypic models in healthy and diseased states. To achieve that, biomimetic microenvironment that provides all the needed stimuli (electrical, mechanical, topological (3D environment) and biochemical (release of active molecules)), during the maturation of hiPSC-CMs will be developed. This will be achieved by combining electromechanoactive polymer-based scaffolds (EMAPS) with bioactive membranes. To characterize the effects of CVD drugs, the contractility of the microtissue will be monitored continuously and simultaneously (over 24-wells) using the sensors developed during the project. To increase the sensitivity and accuracy of the model, deep-learning based algorithms to detect the effects of drugs in vitro will be developed and verified. The goals will be achieved by a multidisciplinary consortium with complementary know-how of three academic units and seven small companies. The increased sensitivity and accuracy of organ-on-chip devices is a needed leap in technology that will accelerate new drug development without the need for animal models; the project aims to provide a platform for the realization of such physiologically-relevant organotypic models.

EuroGCT

European consortium for communicating gene- and cell-based therapy information

H2020-SC1-BHC-2018-2020 (Call for Better Health and care, economic growth and sustainable health systems)

Number of Participants: 49
Role: Partner
Project number: H2020-SC1-BHC-2018-2020- 965241

Objective: The European Consortium for Communicating Gene and Cell Therapy Information (EuroGCT) unites 49 partner organisations and institutions across Europe, including the major European advanced therapies learned societies, with the common goal of providing reliable and accessible information related to cell and gene therapy development to European stakeholders. EuroGCT has two major objectives:

  • To provide patients, people affected by conditions, healthcare professionals and citizens with accurate scientific, legal, ethical and societal information and with engagement opportunities, and thus to support better informed decisionmaking related to cell and gene-based therapies.
  • To facilitate better decision-making at key points in development of new therapies and thus enable improved product development, by providing the research community and regulatory and healthcare authorities with an information source on the practical steps needed for cell and gene therapy development.

To achieve our aims, EuroGCT will adopt a highly structured system for coordinated management of information related to cell and gene therapy development and, from this, will implement an ambitious programme of online and direct stakeholder information provision and engagement. All outputs will be delivered in 7 European languages, to ensure broad accessibility, and will be rigorously evaluated against measurable objectives throughout the project duration. The proposed consortium comprises leading cell and gene therapy-related organisations and basic and clinical research labs across Europe, including new member states; together with experts in product development, ethical, legal and societal issues, and in evaluating clinical outcomes; patient representatives; and science communicators. It thus is uniquely placed to develop a world-leading cell and gene therapy information resource and to meet the challenge outlined in Topic SC1-HCO-19-2020.

Ongoing national projects

ADAIR

ADAIR: A légszennyezéstől az agyszennyezésig – új biomarkerek, amelyek feltárják a kapcsolatot a légszennyezés és az Alzheimer-kór között

Pályázati program: “ERA-NET COFUND és EJP COFUND programok közös nemzetközi pályázati program”

Magyar partner csatlakozás
Támogatási szerződés száma: 2019-2.1.7-ERA-NET-2020-00007

Támogatási szerződés hatályba lépésének dátuma: 2020. december 9.

Projekt website:  https://adair-jpnd.eu/

Projekt tartalma:

Az Alzheimer-kór (AD) molekuláris patomechanizmusa nem pontosan ismert, a kezelések jelenleg nem megfelelőek. Kevés figyelmet fordítanak a környezeti tényezők szerepére, amelyek az epidemiológiai vizsgálatok adatai alapján az AD kialakulását befolyásolhatják. Egyre több epidemiológiai és állatkísérletes bizonyíték azt mutatja, hogy a légszennyező anyagoknak való kitettség károsítja az agyat. Emellett, az erősen szennyezett területeken élőknél a szennyezés súlyosbítja a kognitív diszfunkciót és az AD megjelenését. Sok kérdés azonban továbbra is megválaszolatlan, mivel a légszennyező anyagok hatásaira vonatkozó információk igen szűkösek. Fontos megjegyezni, hogy jelenleg nem léteznek a légszennyezés és az AD-kockázatának becslésére szolgáló biomarkerek, ami akadályozza a káros légszennyezés hatásának kitett egyének azonosítását és stratifikálását. A neurobiológia, az epidemiológia, a klinikai tudományok, a környezettudomány és az adattudomány területén a szakértelem és a legkorszerűbb módszerek és eszközök egyedülálló kombinációjára támaszkodva az ADAIR konzorcium kivételes helyzetben van, hogy elsőként döntő fontosságú mechanisztikus betekintést nyerjen a légszennyező anyagok emberi agyra gyakorolt hatását illetően, biomarkereket azonosítson a légszennyezés és az AD kockázat előrejelzésére. A projekt azt az új, ambiciózus hipotézist vizsgálja, amely szerint az egyén szennyezőanyag-expozíciós környezete megváltoztatja a sejtmechanizmusokat és funkciókat, ami mérhető biomarkerek kifejeződését eredményezi. Az ADAIR az egészséggel kapcsolatos, nagy kiterjedésű, nagy egészségügyi, környezeti, gazdasági, tudományos, társadalmi és politikai hatással járó jelentős társadalmi kihívásokkal foglalkozik.

A végső cél az, hogy stratégiákat dolgozzanak ki az AD kockázatának kitett emberek korai azonosítására, és új célokat találjanak a megelőző stratégiákra vonatkozóan, amelyek képesek csökkenteni az egészségügyi ellátást és a társadalmi-gazdasági terheket.

Magyar-Kínai TÉT

Új őssejt-alapú, a fejlődő magzati agyra gyakorolt mikotoxin hatást kimutató rendszerek fejlesztése

Pályázati program: “KÉTOLDALÚ TUDOMÁNYOS ÉS TECHNOLÓGIAI (TÉT) EGYÜTTMŰKÖDÉS TÁMOGATÁSA, Magyar-Kínai”
Támogatási szerződés száma2018-2.1.14-TÉT-CN-2018-00011

Támogatási szerződés hatályba lépésének dátuma:  2019.06.20

Projekt tartalma: 

Az egészséges élethez való elemi jog érvényesítésének egyik fontos eleme az élelmiszerbiztonság. A magvakon, tárolt élelmiszereken (kukorica, búza, kávé, fűszerek, fermentált termékek) elszaporodó gombák által termelt mikotoxinok közvetlenül, vagy takarmányként felhasználva állati hús és tejtermékek fogyasztásán keresztül súlyos egészségkárosodást okozhatnak, Kínában a magas szennyezettség is felelős az emésztőszervi- és májrák esetek gyakori előfordulásáért. Az állattenyésztésben szintén jelentős gazdasági veszteségeket okoznak a mikotoxinok. A mikotoxinok jelenlétének kimutatása jelenleg fiziko-kémiai, nagy érzékenységű módszerekkel történik. Ezek hatékonyak, de kémiailag instabil, vagy új, még nem ismert hatású toxinok és mikotoxin keverékek esetében a komplex biológiai hatás mérésére nem alkalmasak. Az EU etikai és gazdasági okok miatt határozottan támogatja az állatkísérlet-helyettesítő alternatívákat. A jelen projekt a humán toxicitás vizsgálatok laboratóriumi állatkísérleteinek alternatív módszerekkel történő kiváltására irányul, biotechnológiai eszközökkel előállított emberi sejtkultúra alapú módszerek alkalmazásával, egy anyai placenta és magzati fejlődő központi idegrendszer kombinált modell létrehozásával.

Konkrét célunk, hogy kifejlesszünk és alkalmazzunk egy humán pluripotens őssejt alapú neurotoxikológiai vizsgálati rendszert, amely hatékonyan képes jelezni az egyes gombatoxinok és keverékeik humán neurotoxicitását. Vizsgálatunk tárgyát olyan gombatoxinok képezik, melyek a projektben résztvevő kínai partnerek placenta modell vizsgálataiban kimutathatóan átjutnak az anyai méhlepény gáton, így potenciálisan károsíthatják a fejlődő magzati idegrendszert. A projekt végső célja, hogy hozzájáruljon a jobb élelmiszerbiztonság létrejöttéhez, a következő generációk egészségmegőrzéséhez, mely jelentős társadalmi és gazdasági hozzáadott értéket jelent, és a projekt támogatás gyors gazdasági megtérüléséhez vezet

Projektek az NKFIH ALAPBÓL megvalósuló programok

Closed H2020 projects

CaSR

Calcium-Sensing Receptor (CaSR): Therapeutics for Non-Communicable Diseases

EU H2020 Marie Sklodowska-Curie Innovative Training Networks (ITN)
Participant’s number: 13
Role: Partner
Project number: H2020-MSCA-ITN-2015 – 675228
Project website:casr.meduniwien.ac.at/

Objective: The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer, which account for >25% of the global disease burden. The CaSR is a unique GPCR whose principal physiological ligand is the Ca2+ ion; it is expressed almost ubiquitously; interacts with multiple Gα subtypes regulating highly divergent downstream signalling pathways, depending on the cellular context. The CaSR Biomedicine is a fully translational project that utilises the concept of a single molecule, the CaSR, influencing a range of physiological and disease processes, to develop a unique, strong multidisciplinary and intersectoral scientific training programme preparing 14 young scientists to become specialists in GPCR biology and signalling.The objectives of CaSR Biomedicine are:1. Educate and train Early Stage Researchers to become highly innovative scientists to enhance their career perspective. 2. Elucidate ligand- and tissuedependent differences in CaSR physiology by examining its functions at cellular level and thus to contribute to the understanding of GPCR signalling in general; 3. Assess how CaSR function is altered in AD, CVD, DM, sarcopenia, and cancer, and to find innovative CaSR-based therapeutic approaches for these major, age-related disorders.4. Establish long-lasting interdisciplinary and intersectoral cooperation among researchers and between researchers and industry, to strengthen the European Research Area.Therefore the CaSR Biomedicine will investigate the complexity of CaSR signalling and function to identify CaSR-based therapeutic approaches to diseases linked to changes in CaSR expression or function (AD, CVD, DM, sarcopenia, and cancer).

SCICHALLENGE

Next Generation Science Challenges Using Digital and Social Media to Make Science Education and Careers Attractive for Young People

EU H2020 Industrial Leadership and Societal Challenges Department, Spreading Excellence, Widening Participation, Science with and for Society (SEAC)
Participant’s number: 9
Role: Partner
Project number: H2020-SEAC-2014-2015 – 665868
Project website: www.scichallenge.eu

Objective: Science education is tremendous in shaping the present and future of modern societies. Thus, the EU needs all its talents to increase creativity and competitiveness. Especially young boys and girls have to be engaged to pursue careers in Science, Technology, Engineering and Mathematics (STEM). However, statistics still show that enrolment rates in STEM-based degree programs are low and will lead to a workforce problem in industries, especially in many of the new member countries. The SciChallenge project focuses on developing novel concepts to actively integrate young boys and girls in science education using a contest-based approach to self-produced digital education materials from young people for young people. Driven by inspirational topic sheets, guides and toolkits created through this project and distributed by partner schools, teachers, and other youth-oriented institutions, contestants (individuals or groups) between the ages of 10 to 20 will generate creative digital materials (videos, slides, or infographics). The initiative will broadcast and distribute content over various social media channels and aggregated on a modern SciChallenge Web Platform (www.scichallenge.eu) to generate wide reaching awareness and promotion. Winning submissions will receive prizes funded by science-oriented industry and stakeholders. Intelligent cross-sectoral positioning of various awareness modules on the SciChallenge Open Information Hub will increase awareness on science careers and open opportunities for youngsters on internships or taster days in STEM through the strong involvement of related organisations and industries. Additionally aggregated information on science events (slams, nights, festivals etc.) is shared. With this multi-level approach, SciChallenge will boost the attractiveness of science education and careers among young girls and boys leading to more public engagement in science, economic prosperity and global competitiveness on a pan-European level.

NABBA

Design and development of advanced NAnomedicines to overcome Biological Barriers and to treat severe diseases

EU H2020 Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN)
Participant’s number: 6
Role: Associated Partner
Project number: H2020-MSCA-ITN-2014- 642028
Project website: www.nabbaproject.eu

Objective: Many therapeutic targets are shielded behind biological barriers, limiting the possibility to reach them with conventional drugs or diagnostic probes. Biological barriers are even more problematic for most biological pharmaceutics, such as recombinant proteins, antibodies and gene therapeutics. The most promising solution to this challenge is the use of nano-vehicles for specific targeting and delivery. The aim of NABBA is to form European early stage researchers (ESR) with cutting-edge scientific knowledge in the field of nanoparticles (NP) for biomedical application, able to cross biological barriers. For this aim the project will train ESRs, focusing on key aspects of nanobiotechnology: (i) design and chemical synthesis of different types of NPs, (ii) related techniques of detection and characterization, (iii) strategies of loading, targeting and delivery of drugs or diagnostic probes; (iv) proof of principle of pharmacological activity including pharmacokinetics and biodistribution. As a peculiar feature of NABBA, strong emphasis will be devoted to molecular mechanisms ruling biological barriers under physiological and pathological conditions, in order to develop novel nano-technological expedients for their crossing. Strong emphasis will be devoted to advanced chemistry issues, enabling new synthetic strategies either for NP assembly or functionalization. Different biological barriers will be addressed. ESRs will strongly benefit from a network of internationally recognized scientists in the field of chemistry, nanobiotechnology and nanomedicine, and the participation of companies with relevant interests and expertises in the field. The planned cooperation programs between Academia and Industries will allow the circulation of ESRs and this will give them the opportunity for to get acquainted with the most advanced research in the field, the most sophisticated technologies and the most advanced Industrial manufacturing platforms and innovative strategies.

The projects have received funding from the European Union’s Horizon 2020

Closed FP6 and FP7 projects

AGLAEA: Development of novel animal models of glutamatergic central nervous system disorders using in vivo sirna and transgenic approaches

Grant agreement ID: 37554

https://cordis.europa.eu/project/id/37554
 

AniStem: Induced pluripotent stem cells in rabbit, pig

Grant agreement ID: 286264

https://cordis.europa.eu/project/id/286264

 

CLONET: Training Network on novel animal models for medical purposes

Grant agreement ID: 35468

https://cordis.europa.eu/project/id/35468

 

D-Board: Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases

Grant agreement ID: 305815

https://cordis.europa.eu/project/id/305815

 

EpiHealth: Linking perturbed maternal environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing

Grant agreement ID: 278418

https://cordis.europa.eu/project/id/278418

 

EpiHealthNet

Grant agreement ID: 317146

https://cordis.europa.eu/project/id/317146

 

IDPbyNMR: High resolution tools to understand the functional role of protein intrinsic disorder

Grant agreement ID: 264257

https://cordis.europa.eu/project/id/264257

 

INDUHEART: Induced pluripotent stem cells for cardiomyocyte generation in mouse

Grant agreement ID: 234390

https://cordis.europa.eu/project/id/234390

 

INDUSTEM: Comparative stem cell research in mouse and humans

Grant agreement ID: 230675

https://cordis.europa.eu/project/id/230675

 

INDUVIR: Improved gene transfer system to iPS cells in mouse

Grant agreement ID: 245808

https://cordis.europa.eu/project/id/245808

 

NanoS3: Novel nanoparticles — Structure and dynamics

Grant agreement ID: 290251

https://cordis.europa.eu/project/id/290251

 

RabPStem: Comparative Analysis of Rabbit and Mouse Pluripotency in Embryos and Stem Cells

Grant agreement ID: 268422

https://cordis.europa.eu/project/id/268422

 

PepStem: Effect of neuropeptides on selective neuronal differentiation of mouse
embryonic stem cells

Grant agreement ID: 268471

https://cordis.europa.eu/project/id/268471

 

RESOLVE: Resolve Chronic Inflammation and Achieve Healthy Aging by Understanding Non-regenerative Repair

Grant agreement ID: 202047

https://cordis.europa.eu/project/id/202047

 

PluriSys: Systems biology approaches to understand cell pluripotency

Grant agreement ID: 223485

https://cordis.europa.eu/project/id/223485

 

STEMCAM: A IAPP on the Role of NCAM in Stem Cell Differentiation

Grant agreement ID: 251186

https://cordis.europa.eu/project/id/251186

 

STEMMAD: Patient-specific stem cell-derived models for Alzheimer’s disease and related neurodegenerative

Grant agreement ID: 324451

https://cordis.europa.eu/project/id/324451

 

XENOISLET: Macroencapsulated Porcine Pancreatic Islets to cure Diabetes Mellitus type ½

Grant agreement ID: 601827

https://cordis.europa.eu/project/id/601827

Closed national projects

Számos Európai Unió horizon 2020 programjában, valamint egyéb EU regionális programban való magyar részvétel ösztönzése úgynevezett EU-KP programban nyert pályázatok

GINOP-2.2.1-15-2016-00009

Reagens és szolgáltatás csomag kialakítása gyógyszerek abszorpciójának – disztribúciójának – metabolizmusának – eliminációjának (ADME) vizsgálatához

Project number: GINOP-2.2.1-15-2016-00009
Project website: https://www.solvobiotech.com/grants/ginop-2.2.1-15-2016-00009

Objective: A pályázat a gyógyszerek transzportjának és metabolizmusának vizsgálatára olyan reagens és szolgáltatás portfóliót fejleszt, amely azonfelül, hogy hiánypótló a piacon, i) segíti a gyógyszerkutató – fejlesztő cégek és a gyógyszerhatóságok munkáját valamint ii) a gyógyszertranszport jelentőségének megértését. A konzorciumvezető a multidiszciplináris feladatot akadémiai, egyetemi intézetek, kis- és mikrovállalkozások hozzájárulásával igyekszik megvalósítani.

Támogatta az Európai Unió Európai Strukturális és Beruházási Alapok